Holzman T - Search Results

1

A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.

Gu WZ, Joseph I, Wang YC, Frost D, Sullivan GM, Wang L, Lin NH, Cohen J, Stoll VS, Jakob CG, Muchmore SW, Harlan JE, Holzman T, Walten KA, Ladror US, Anderson MG, Kroeger P, Rodriguez LE, Jarvis KP, Ferguson D, Marsh K, Ng S, Rosenberg SH, Sham HL, Zhang H. Gu WZ, et al. Among authors: holzman t. Anticancer Drugs. 2005 Nov;16(10):1059-69. doi: 10.1097/00001813-200511000-00004. Anticancer Drugs. 2005. PMID: 16222147

2

Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.

Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, Stoll VS. Longenecker KL, et al. Protein Sci. 2005 Dec;14(12):3039-47. doi: 10.1110/ps.051604805. Protein Sci. 2005. PMID: 16322581 Free PMC article.

3

Characterization of protein kinase A phosphorylation: multi-technique approach to phosphate mapping.

Shen J, Smith RA, Stoll VS, Edalji R, Jakob C, Walter K, Gramling E, Dorwin S, Bartley D, Gunasekera A, Yang J, Holzman T, Johnson RW. Shen J, et al. Among authors: holzman t. Anal Biochem. 2004 Jan 15;324(2):204-18. doi: 10.1016/j.ab.2003.09.016. Anal Biochem. 2004. PMID: 14690684

4

Cleavage of fluorogenic substrates for APP-processing proteases by human brain extracts. Ca(2+)-substrate interaction is responsible for Ca2+ stimulation of the neural protease activity.

Wang GT, Ladror US, Holzman TF, Klein WL, Krafft GA. Wang GT, et al. Among authors: holzman tf. Mol Chem Neuropathol. 1994 Oct-Dec;23(2-3):191-9. doi: 10.1007/BF02815411. Mol Chem Neuropathol. 1994. PMID: 7702708

5

Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D.

Ladror US, Snyder SW, Wang GT, Holzman TF, Krafft GA. Ladror US, et al. Among authors: holzman tf. J Biol Chem. 1994 Jul 15;269(28):18422-8. J Biol Chem. 1994. PMID: 8034590 Free article.

6

Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.

Bussiere DE, Muchmore SW, Dealwis CG, Schluckebier G, Nienaber VL, Edalji RP, Walter KA, Ladror US, Holzman TF, Abad-Zapatero C. Bussiere DE, et al. Among authors: holzman tf. Biochemistry. 1998 May 19;37(20):7103-12. doi: 10.1021/bi973113c. Biochemistry. 1998. PMID: 9585521

7

Driving affinity selection by centrifugal force.

Harlan JE, Egan DA, Ladror US, Snyder S, Tang MI, Buko A, Holzman TF. Harlan JE, et al. Among authors: holzman tf. Assay Drug Dev Technol. 2003 Aug;1(4):507-19. doi: 10.1089/154065803322302763. Assay Drug Dev Technol. 2003. PMID: 15090247

8

Potential beta PP-processing proteinase activities from Alzheimer's and control brain tissues.

Ladror US, Wang GT, Klein WL, Holzman TF, Krafft GA. Ladror US, et al. Among authors: holzman tf. J Protein Chem. 1994 May;13(4):357-66. doi: 10.1007/BF01901691. J Protein Chem. 1994. PMID: 7986341

9

Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition.

Luo Y, Smith RA, Guan R, Liu X, Klinghofer V, Shen J, Hutchins C, Richardson P, Holzman T, Rosenberg SH, Giranda VL. Luo Y, et al. Among authors: holzman t. Biochemistry. 2004 Feb 10;43(5):1254-63. doi: 10.1021/bi034515p. Biochemistry. 2004. PMID: 14756561

10

Cathepsin D from Alzheimer's-diseased and normal brains.

Kohnken RE, Ladror US, Wang GT, Holzman TF, Miller BE, Krafft GA. Kohnken RE, et al. Among authors: holzman tf. Exp Neurol. 1995 Jun;133(2):105-12. doi: 10.1006/exnr.1995.1013. Exp Neurol. 1995. PMID: 7649217

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