Spiteller D - Search Results

1

Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.

Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Siskos AP, et al. Among authors: spiteller d. Chem Biol. 2005 Oct;12(10):1145-53. doi: 10.1016/j.chembiol.2005.08.017. Chem Biol. 2005. PMID: 16242657

2

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM, Spiteller D, Williams MG, Campillo N, Spencer JB, Leadlay PF. Baerga-Ortiz A, et al. Among authors: spiteller d. Chem Biol. 2006 Mar;13(3):277-85. doi: 10.1016/j.chembiol.2006.01.004. Chem Biol. 2006. PMID: 16638533

3

A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue.

Spiteller D, Waterman CL, Spencer JB. Spiteller D, et al. Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7079-82. doi: 10.1002/anie.200501670. Angew Chem Int Ed Engl. 2005. PMID: 16208728 No abstract available.

4

The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.

Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB. Huang F, et al. Among authors: spiteller d. Chem Biol. 2006 May;13(5):475-84. doi: 10.1016/j.chembiol.2006.02.014. Chem Biol. 2006. PMID: 16720268

5

Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization.

Hong H, Spiteller D, Spencer JB. Hong H, et al. Among authors: spiteller d. Angew Chem Int Ed Engl. 2008;47(32):6028-32. doi: 10.1002/anie.200801100. Angew Chem Int Ed Engl. 2008. PMID: 18613185 No abstract available.

6

Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates.

Tosin M, Spiteller D, Spencer JB. Tosin M, et al. Among authors: spiteller d. Chembiochem. 2009 Jul 6;10(10):1714-23. doi: 10.1002/cbic.200900093. Chembiochem. 2009. PMID: 19507202

7

Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.

Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Dias MV, et al. Among authors: spiteller d. J Biol Chem. 2010 Jul 16;285(29):22495-504. doi: 10.1074/jbc.M110.107177. Epub 2010 Apr 29. J Biol Chem. 2010. PMID: 20430898 Free PMC article.

8

Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII.

Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF. Moncrieffe MC, et al. Among authors: spiteller d. J Mol Biol. 2012 Jan 6;415(1):92-101. doi: 10.1016/j.jmb.2011.10.036. Epub 2011 Oct 25. J Mol Biol. 2012. PMID: 22056329 Free PMC article.

9

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.

Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, Spencer JB. Huang F, et al. Among authors: spiteller d. Org Biomol Chem. 2005 Apr 21;3(8):1410-8. doi: 10.1039/b501199j. Epub 2005 Mar 21. Org Biomol Chem. 2005. PMID: 15827636

10

Identification of a pentaketide stilbene produced by a type III polyketide synthase from Pinus sylvestris and characterisation of free coenzyme A intermediates.

Li TL, Spiteller D, Spencer JB. Li TL, et al. Among authors: spiteller d. Chembiochem. 2009 Mar 23;10(5):896-901. doi: 10.1002/cbic.200800840. Chembiochem. 2009. PMID: 19266535

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