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Page 1
First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Linton SD, Aja T, Armstrong RA, Bai X, Chen LS, Chen N, Ching B, Contreras P, Diaz JL, Fisher CD, Fritz LC, Gladstone P, Groessl T, Gu X, Herrmann J, Hirakawa BP, Hoglen NC, Jahangiri KG, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs J, McQuiston J, Meduna SP, Nalley K, Robinson ED, Sayers RO, Sebring K, Spada AP, Ternansky RJ, Tomaselli KJ, Ullman BR, Valentino KL, Weeks S, Winn D, Wu JC, Yeo P, Zhang CZ. Linton SD, et al. Among authors: herrmann j. J Med Chem. 2005 Nov 3;48(22):6779-82. doi: 10.1021/jm050307e. J Med Chem. 2005. PMID: 16250635
Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.
Ullman BR, Aja T, Deckwerth TL, Diaz JL, Herrmann J, Kalish VJ, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC. Ullman BR, et al. Among authors: herrmann j. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3623-6. doi: 10.1016/s0960-894x(03)00755-8. Bioorg Med Chem Lett. 2003. PMID: 14505683
Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC. Linton SD, et al. Among authors: herrmann j. Bioorg Med Chem Lett. 2004 May 17;14(10):2685-91. doi: 10.1016/j.bmcl.2003.12.106. Bioorg Med Chem Lett. 2004. PMID: 15109679
Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.
Ullman BR, Aja T, Chen N, Diaz JL, Gu X, Herrmann J, Kalish VJ, Karanewsky DS, Kodandapani L, Krebs JJ, Linton SD, Meduna SP, Nalley K, Robinson ED, Roggo SP, Sayers RO, Schmitz A, Ternansky RJ, Tomaselli KJ, Wu JC. Ullman BR, et al. Among authors: herrmann j. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3632-6. doi: 10.1016/j.bmcl.2005.05.036. Bioorg Med Chem Lett. 2005. PMID: 15964758
Antinociceptive (aminoalkyl)indoles.
Bell MR, D'Ambra TE, Kumar V, Eissenstat MA, Herrmann JL Jr, Wetzel JR, Rosi D, Philion RE, Daum SJ, Hlasta DJ, et al. Bell MR, et al. Among authors: herrmann jl jr. J Med Chem. 1991 Mar;34(3):1099-110. doi: 10.1021/jm00107a034. J Med Chem. 1991. PMID: 1900533
Antiandrogenic steroidal sulfonylpyrazoles.
Christiansen RG, Bell MR, D'Ambra TE, Mallamo JP, Herrmann JL, Ackerman JH, Opalka CJ, Kullnig RK, Winneker RC, Snyder BW, et al. Christiansen RG, et al. Among authors: herrmann jl. J Med Chem. 1990 Aug;33(8):2094-100. doi: 10.1021/jm00170a008. J Med Chem. 1990. PMID: 2374140
Androgen receptor affinity of 5'-acyl furanosteroids.
Kumar V, Ackerman JH, Alexander MD, Bell MR, Christiansen RG, Dung JS, Jaeger EP, Herrmann JL Jr, Krolski ME, McKloskey P, et al. Kumar V, et al. Among authors: herrmann jl jr. J Med Chem. 1994 Nov 25;37(24):4227-36. doi: 10.1021/jm00050a019. J Med Chem. 1994. PMID: 7990121
2,097 results