Tutt AN - Search Results

1

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.

McCabe N, Lord CJ, Tutt AN, Martin NM, Smith GC, Ashworth A. McCabe N, et al. Among authors: tutt an. Cancer Biol Ther. 2005 Sep;4(9):934-6. doi: 10.4161/cbt.4.9.2141. Epub 2005 Sep 1. Cancer Biol Ther. 2005. PMID: 16251802 Free article.

2

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.

Tutt A, Gabriel A, Bertwistle D, Connor F, Paterson H, Peacock J, Ross G, Ashworth A. Tutt A, et al. Curr Biol. 1999 Oct 7;9(19):1107-10. doi: 10.1016/s0960-9822(99)80479-5. Curr Biol. 1999. PMID: 10531007 Free article.

3

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.

Tutt A, Bertwistle D, Valentine J, Gabriel A, Swift S, Ross G, Griffin C, Thacker J, Ashworth A. Tutt A, et al. EMBO J. 2001 Sep 3;20(17):4704-16. doi: 10.1093/emboj/20.17.4704. EMBO J. 2001. PMID: 11532935 Free PMC article.

4

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.

Tutt AN, van Oostrom CT, Ross GM, van Steeg H, Ashworth A. Tutt AN, et al. EMBO Rep. 2002 Mar;3(3):255-60. doi: 10.1093/embo-reports/kvf037. Epub 2002 Feb 15. EMBO Rep. 2002. PMID: 11850397 Free PMC article.

5

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.

Gudmundsdottir K, Lord CJ, Witt E, Tutt AN, Ashworth A. Gudmundsdottir K, et al. Among authors: tutt an. EMBO Rep. 2004 Oct;5(10):989-93. doi: 10.1038/sj.embor.7400255. Epub 2004 Sep 10. EMBO Rep. 2004. PMID: 15359272 Free PMC article.

6

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Farmer H, et al. Among authors: tutt an. Nature. 2005 Apr 14;434(7035):917-21. doi: 10.1038/nature03445. Nature. 2005. PMID: 15829967 Free article.

7

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.

Iorns E, Turner NC, Elliott R, Syed N, Garrone O, Gasco M, Tutt AN, Crook T, Lord CJ, Ashworth A. Iorns E, et al. Among authors: tutt an. Cancer Cell. 2008 Feb;13(2):91-104. doi: 10.1016/j.ccr.2008.01.001. Cancer Cell. 2008. PMID: 18242510 Free article.

8

BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years.

Robertson L, Hanson H, Seal S, Warren-Perry M, Hughes D, Howell I, Turnbull C, Houlston R, Shanley S, Butler S, Evans DG, Ross G, Eccles D, Tutt A, Rahman N; TNT Trial TMG; BCSC (UK). Robertson L, et al. Br J Cancer. 2012 Mar 13;106(6):1234-8. doi: 10.1038/bjc.2012.31. Epub 2012 Feb 14. Br J Cancer. 2012. PMID: 22333603 Free PMC article.

9

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.

Lord CJ, Tutt AN, Ashworth A. Lord CJ, et al. Among authors: tutt an. Annu Rev Med. 2015;66:455-70. doi: 10.1146/annurev-med-050913-022545. Epub 2014 Oct 17. Annu Rev Med. 2015. PMID: 25341009 Review.

10

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Watkins J, Weekes D, Shah V, Gazinska P, Joshi S, Sidhu B, Gillett C, Pinder S, Vanoli F, Jasin M, Mayrhofer M, Isaksson A, Cheang MC, Mirza H, Frankum J, Lord CJ, Ashworth A, Vinayak S, Ford JM, Telli ML, Grigoriadis A, Tutt AN. Watkins J, et al. Among authors: tutt an. Cancer Discov. 2015 May;5(5):488-505. doi: 10.1158/2159-8290.CD-14-1092. Epub 2015 Mar 13. Cancer Discov. 2015. PMID: 25770156 Free PMC article.

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