Young WB - Search Results

1

Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation.

Young WB, Sprengeler P, Shrader WD, Li Y, Rai R, Verner E, Jenkins T, Fatheree P, Kolesnikov A, Janc JW, Cregar L, Elrod K, Katz B. Young WB, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):710-3. doi: 10.1016/j.bmcl.2005.10.023. Epub 2005 Oct 27. Bioorg Med Chem Lett. 2006. PMID: 16257204

2

Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity.

Rice KD, Wang VR, Gangloff AR, Kuo EY, Dener JM, Newcomb WS, Young WB, Putnam D, Cregar L, Wong M, Simpson PJ. Rice KD, et al. Among authors: young wb. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2361-6. doi: 10.1016/s0960-894x(00)00485-6. Bioorg Med Chem Lett. 2000. PMID: 11055356

3

Perspectives on factor Xa inhibition.

Rai R, Sprengeler PA, Elrod KC, Young WB. Rai R, et al. Among authors: young wb. Curr Med Chem. 2001 Feb;8(2):101-19. doi: 10.2174/0929867013373822. Curr Med Chem. 2001. PMID: 11172669 Review.

4

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.

Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. Katz BA, et al. J Mol Biol. 2001 Apr 13;307(5):1451-86. doi: 10.1006/jmbi.2001.4516. J Mol Biol. 2001. PMID: 11292354

5

Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.

Dener JM, Rice KD, Newcomb WS, Wang VR, Young WB, Gangloff AR, Kuo EY, Cregar L, Putnam D, Wong M. Dener JM, et al. Among authors: young wb. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1629-33. doi: 10.1016/s0960-894x(01)00254-2. Bioorg Med Chem Lett. 2001. PMID: 11425524

6

Development of potent and selective factor Xa inhibitors.

Rai R, Kolesnikov A, Li Y, Young WB, Leahy E, Sprengeler PA, Verner E, Shrader WD, Burgess-Henry J, Sangalang JC, Allen D, Chen X, Katz BA, Luong C, Elrod K, Cregar L. Rai R, et al. Among authors: young wb. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1797-800. doi: 10.1016/s0960-894x(01)00311-0. Bioorg Med Chem Lett. 2001. PMID: 11459634

7

Neutral inhibitors of the serine protease factor Xa.

Shrader WD, Young WB, Sprengeler PA, Sangalang JC, Elrod K, Carr G. Shrader WD, et al. Among authors: young wb. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1801-4. doi: 10.1016/s0960-894x(01)00312-2. Bioorg Med Chem Lett. 2001. PMID: 11459635

8

Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

Verner E, Katz BA, Spencer JR, Allen D, Hataye J, Hruzewicz W, Hui HC, Kolesnikov A, Li Y, Luong C, Martelli A, Radika K, Rai R, She M, Shrader W, Sprengeler PA, Trapp S, Wang J, Young WB, Mackman RL. Verner E, et al. Among authors: young wb. J Med Chem. 2001 Aug 16;44(17):2753-71. doi: 10.1021/jm0100638. J Med Chem. 2001. PMID: 11495587

9

Optimization of a screening lead for factor VIIa/TF.

Young WB, Kolesnikov A, Rai R, Sprengeler PA, Leahy EM, Shrader WD, Sangalang J, Burgess-Henry J, Spencer J, Elrod K, Cregar L. Young WB, et al. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2253-6. doi: 10.1016/s0960-894x(01)00420-6. Bioorg Med Chem Lett. 2001. PMID: 11527709

10

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Katz BA, et al. Among authors: young wb. J Mol Biol. 2004 Nov 19;344(2):527-47. doi: 10.1016/j.jmb.2004.09.032. J Mol Biol. 2004. PMID: 15522303

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