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Page 1
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD. Durgam GG, et al. Among authors: tsukahara r. J Med Chem. 2005 Jul 28;48(15):4919-30. doi: 10.1021/jm049609r. J Med Chem. 2005. PMID: 16033271
Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma.
Tsukahara T, Tsukahara R, Yasuda S, Makarova N, Valentine WJ, Allison P, Yuan H, Baker DL, Li Z, Bittman R, Parrill A, Tigyi G. Tsukahara T, et al. Among authors: tsukahara r. J Biol Chem. 2006 Feb 10;281(6):3398-407. doi: 10.1074/jbc.M510843200. Epub 2005 Dec 1. J Biol Chem. 2006. PMID: 16321982 Free article.
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis.
Baker DL, Fujiwara Y, Pigg KR, Tsukahara R, Kobayashi S, Murofushi H, Uchiyama A, Murakami-Murofushi K, Koh E, Bandle RW, Byun HS, Bittman R, Fan D, Murph M, Mills GB, Tigyi G. Baker DL, et al. Among authors: tsukahara r. J Biol Chem. 2006 Aug 11;281(32):22786-93. doi: 10.1074/jbc.M512486200. Epub 2006 Jun 16. J Biol Chem. 2006. PMID: 16782709 Free PMC article.
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.
Deng W, Shuyu E, Tsukahara R, Valentine WJ, Durgam G, Gududuru V, Balazs L, Manickam V, Arsura M, VanMiddlesworth L, Johnson LR, Parrill AL, Miller DD, Tigyi G. Deng W, et al. Among authors: tsukahara r. Gastroenterology. 2007 May;132(5):1834-51. doi: 10.1053/j.gastro.2007.03.038. Epub 2007 Mar 24. Gastroenterology. 2007. PMID: 17484878 Free PMC article.
Identification of non-lipid LPA3 antagonists by virtual screening.
Fells JI, Tsukahara R, Fujiwara Y, Liu J, Perygin DH, Osborne DA, Tigyi G, Parrill AL. Fells JI, et al. Among authors: tsukahara r. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17. doi: 10.1016/j.bmc.2008.04.035. Epub 2008 Apr 18. Bioorg Med Chem. 2008. PMID: 18467108 Free PMC article.
Structure-based drug design identifies novel LPA3 antagonists.
Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Fells JI, et al. Among authors: tsukahara r. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64. doi: 10.1016/j.bmc.2009.09.022. Epub 2009 Sep 18. Bioorg Med Chem. 2009. PMID: 19800804 Free PMC article.
129 results