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Page 1
P3 cap modified Phe*-Ala series BACE inhibitors.
Chen SH, Lamar J, Guo D, Kohn T, Yang HC, McGee J, Timm D, Erickson J, Yip Y, May P, McCarthy J. Chen SH, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):245-50. doi: 10.1016/j.bmcl.2003.09.085. Bioorg Med Chem Lett. 2004. PMID: 14684336
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
Bueno AB, Agejas J, Broughton H, Dally R, Durham TB, Espinosa JF, González R, Hahn PJ, Marcos A, Rodríguez R, Sanz G, Soriano JF, Timm D, Vidal P, Yang HC, McCarthy JR. Bueno AB, et al. Among authors: mccarthy jr. J Med Chem. 2017 Dec 14;60(23):9807-9820. doi: 10.1021/acs.jmedchem.7b01304. Epub 2017 Nov 28. J Med Chem. 2017. PMID: 29088532
Design and synthesis of statine-containing BACE inhibitors.
Hu J, Cwi CL, Smiley DL, Timm D, Erickson JA, McGee JE, Yang HC, Mendel D, May PC, Shapiro M, McCarthy JR. Hu J, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4335-9. doi: 10.1016/j.bmcl.2003.09.037. Bioorg Med Chem Lett. 2003. PMID: 14643321
Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC. Yang HC, et al. Among authors: mccarthy jr. J Neurochem. 2004 Dec;91(6):1249-59. doi: 10.1111/j.1471-4159.2004.02764.x. J Neurochem. 2004. PMID: 15584902 Free article.
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Brooks DA, Etgen GJ, Rito CJ, Shuker AJ, Dominianni SJ, Warshawsky AM, Ardecky R, Paterniti JR, Tyhonas J, Karanewsky DS, Kauffman RF, Broderick CL, Oldham BA, Montrose-Rafizadeh C, Winneroski LL, Faul MM, McCarthy JR. Brooks DA, et al. Among authors: mccarthy jr. J Med Chem. 2001 Jun 21;44(13):2061-4. doi: 10.1021/jm0155188. J Med Chem. 2001. PMID: 11405642
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.
Xu Y, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR. Xu Y, et al. Among authors: mccarthy jr. J Med Chem. 2004 May 6;47(10):2422-5. doi: 10.1021/jm0342616. J Med Chem. 2004. PMID: 15115385
264 results