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Page 1
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.
Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J. Moretto AF, et al. Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. doi: 10.1016/j.bmc.2005.11.005. Epub 2005 Nov 21. Bioorg Med Chem. 2006. PMID: 16303309
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
Xu ZB, Chaudhary D, Olland S, Wolfrom S, Czerwinski R, Malakian K, Lin L, Stahl ML, Joseph-McCarthy D, Benander C, Fitz L, Greco R, Somers WS, Mosyak L. Xu ZB, et al. J Biol Chem. 2004 Nov 26;279(48):50401-9. doi: 10.1074/jbc.M409216200. Epub 2004 Sep 13. J Biol Chem. 2004. PMID: 15364937 Free article.
Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.
Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Joseph-McCarthy D, et al. J Med Chem. 2005 Dec 15;48(25):7960-9. doi: 10.1021/jm050523n. J Med Chem. 2005. PMID: 16335920
Probing acid replacements of thiophene PTP1B inhibitors.
Wan ZK, Follows B, Kirincich S, Wilson D, Binnun E, Xu W, Joseph-McCarthy D, Wu J, Smith M, Zhang YL, Tam M, Erbe D, Tam S, Saiah E, Lee J. Wan ZK, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2913-20. doi: 10.1016/j.bmcl.2007.02.043. Epub 2007 Feb 20. Bioorg Med Chem Lett. 2007. PMID: 17336064
61 results