Higginbottom M - Search Results

1

Leptin-mediated inhibition of the insulin-stimulated increase in fatty acid uptake in differentiated 3T3-L1 adipocytes.

Ho M, Foxall S, Higginbottom M, Donofrio DM, Liao J, Richardson PJ, Maneuf YP. Ho M, et al. Among authors: higginbottom m. Metabolism. 2006 Jan;55(1):8-12. doi: 10.1016/j.metabol.2005.06.013. Metabolism. 2006. PMID: 16324913

2

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

Ashwood V, Brownhill V, Higginbottom M, Horwell DC, Hughes J, Lewthwaite RA, McKnight AT, Pinnock RD, Pritchard MC, Suman-Chauhan N, Webb C, Williams SC. Ashwood V, et al. Among authors: higginbottom m. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94. doi: 10.1016/s0960-894x(98)00462-4. Bioorg Med Chem Lett. 1998. PMID: 9873586

3

Amide bond replacements incorporated into CCK-B selective "dipeptoids".

Fincham CI, Higginbottom M, Hill DR, Horwell DC, O'Toole JC, Ratcliffe GS, Rees DC, Roberts E. Fincham CI, et al. Among authors: higginbottom m. J Med Chem. 1992 Apr 17;35(8):1472-84. doi: 10.1021/jm00086a017. J Med Chem. 1992. PMID: 1573640

4

Quantitative structure-activity relationships (QSARs) of N-terminus fragments of NK1 tachykinin antagonists: a comparison of classical QSARs and three-dimensional QSARs from similarity matrices.

Horwell DC, Howson W, Higginbottom M, Naylor D, Ratcliffe GS, Williams S. Horwell DC, et al. Among authors: higginbottom m. J Med Chem. 1995 Oct 27;38(22):4454-62. doi: 10.1021/jm00022a010. J Med Chem. 1995. PMID: 7473572

5

Cholecystokinin dipeptoid antagonists: design, synthesis, and anxiolytic profile of some novel CCK-A and CCK-B selective and "mixed" CCK-A/CCK-B antagonists.

Boden PR, Higginbottom M, Hill DR, Horwell DC, Hughes J, Rees DC, Roberts E, Singh L, Suman-Chauhan N, Woodruff GN. Boden PR, et al. Among authors: higginbottom m. J Med Chem. 1993 Mar 5;36(5):552-65. doi: 10.1021/jm00057a005. J Med Chem. 1993. PMID: 7684452

6

Rational design of high affinity tachykinin NK1 receptor antagonists.

Boyle S, Guard S, Higginbottom M, Horwell DC, Howson W, McKnight AT, Martin K, Pritchard MC, O'Toole J, Raphy J, et al. Boyle S, et al. Among authors: higginbottom m. Bioorg Med Chem. 1994 May;2(5):357-70. doi: 10.1016/s0968-0896(00)82192-6. Bioorg Med Chem. 1994. PMID: 7922147

7

Conformationally restricted analogues of the potent CCK-B antagonist CI-988.

Higginbottom M, Hill DR, Horwell DC, Mostafai E, Suman-Chauhan N, Roberts E. Higginbottom M, et al. Bioorg Med Chem. 1993 Sep;1(3):209-17. doi: 10.1016/s0968-0896(00)82123-9. Bioorg Med Chem. 1993. PMID: 8081854

8

Rationally designed "dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists.

Higginbottom M, Kneen C, Ratcliffe GS. Higginbottom M, et al. J Med Chem. 1992 May 1;35(9):1572-7. doi: 10.1021/jm00087a011. J Med Chem. 1992. PMID: 1578483

9

The Bannayan syndrome: an autosomal dominant disorder consisting of macrocephaly, lipomas, hemangiomas, and risk for intracranial tumors.

Higginbottom MC, Schultz P. Higginbottom MC, et al. Pediatrics. 1982 May;69(5):632-4. Pediatrics. 1982. PMID: 7079022

10

A second patient with partial deletion of the short arm of chromosome 3: karyotype 46,XY,del(3)(p25).

Higginbottom MC, Mascarello JT, Hassin H, McCord WK. Higginbottom MC, et al. J Med Genet. 1982 Feb;19(1):71-3. doi: 10.1136/jmg.19.1.71. J Med Genet. 1982. PMID: 7069751 Free PMC article.

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