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Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
Forouhar F, Hussain M, Farid R, Benach J, Abashidze M, Edstrom WC, Vorobiev SM, Xiao R, Acton TB, Fu Z, Kim JJ, Miziorko HM, Montelione GT, Hunt JF. Forouhar F, et al. Among authors: benach j. J Biol Chem. 2006 Mar 17;281(11):7533-45. doi: 10.1074/jbc.M507996200. Epub 2005 Dec 5. J Biol Chem. 2006. PMID: 16330546 Free article.
Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif.
Parish D, Benach J, Liu G, Singarapu KK, Xiao R, Acton T, Su M, Bansal S, Prestegard JH, Hunt J, Montelione GT, Szyperski T. Parish D, et al. Among authors: benach j. J Struct Funct Genomics. 2008 Dec;9(1-4):41-9. doi: 10.1007/s10969-008-9050-y. Epub 2008 Nov 26. J Struct Funct Genomics. 2008. PMID: 19039680 Free PMC article.
A community resource of experimental data for NMR / X-ray crystal structure pairs.
Everett JK, Tejero R, Murthy SB, Acton TB, Aramini JM, Baran MC, Benach J, Cort JR, Eletsky A, Forouhar F, Guan R, Kuzin AP, Lee HW, Liu G, Mani R, Mao B, Mills JL, Montelione AF, Pederson K, Powers R, Ramelot T, Rossi P, Seetharaman J, Snyder D, Swapna GV, Vorobiev SM, Wu Y, Xiao R, Yang Y, Arrowsmith CH, Hunt JF, Kennedy MA, Prestegard JH, Szyperski T, Tong L, Montelione GT. Everett JK, et al. Among authors: benach j. Protein Sci. 2016 Jan;25(1):30-45. doi: 10.1002/pro.2774. Epub 2015 Sep 22. Protein Sci. 2016. PMID: 26293815 Free PMC article. Review.
421 results