Douglas KT - Search Results

1

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.

Parveen S, Khan MO, Austin SE, Croft SL, Yardley V, Rock P, Douglas KT. Parveen S, et al. Among authors: douglas kt. J Med Chem. 2005 Dec 15;48(25):8087-97. doi: 10.1021/jm050819t. J Med Chem. 2005. PMID: 16335933

2

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH. Chan C, et al. Among authors: douglas kt. J Med Chem. 1998 Jan 15;41(2):148-56. doi: 10.1021/jm960814j. J Med Chem. 1998. PMID: 9457238

3

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.

Khan MO, Austin SE, Chan C, Yin H, Marks D, Vaghjiani SN, Kendrick H, Yardley V, Croft SL, Douglas KT. Khan MO, et al. Among authors: douglas kt. J Med Chem. 2000 Aug 10;43(16):3148-56. doi: 10.1021/jm000156+. J Med Chem. 2000. PMID: 10956223

4

Inhibitors of trypanothione reductase as potential antitrypanosomal drugs.

Chan C, Yin H, Garforth J, McKie JH, Jaouhari RA, Douglas KT, Fairlamb AH, Croft SL. Chan C, et al. Among authors: douglas kt. Biochem Soc Trans. 1995 Nov;23(4):511S. doi: 10.1042/bst023511s. Biochem Soc Trans. 1995. PMID: 8654696 No abstract available.

5

Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads.

Austin SE, Khan MO, Douglas KT. Austin SE, et al. Among authors: douglas kt. Drug Des Discov. 1999 Jul;16(1):5-23. Drug Des Discov. 1999. PMID: 10466053 Review.

6

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

Reigan P, Edwards PN, Gbaj A, Cole C, Barry ST, Page KM, Ashton SE, Luke RW, Douglas KT, Stratford IJ, Jaffar M, Bryce RA, Freeman S. Reigan P, et al. Among authors: douglas kt. J Med Chem. 2005 Jan 27;48(2):392-402. doi: 10.1021/jm049494r. J Med Chem. 2005. PMID: 15658853

7

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W. McKie JH, et al. Among authors: douglas kt. J Med Chem. 1998 Apr 23;41(9):1367-70. doi: 10.1021/jm970845u. J Med Chem. 1998. PMID: 9554869

8

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

Cole C, Reigan P, Gbaj A, Edwards PN, Douglas KT, Stratford IJ, Freeman S, Jaffar M. Cole C, et al. Among authors: douglas kt. J Med Chem. 2003 Jan 16;46(2):207-9. doi: 10.1021/jm020964w. J Med Chem. 2003. PMID: 12519058

9

Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead.

Chan C, Yin H, McKie JH, Fairlamb AH, Douglas KT. Chan C, et al. Among authors: douglas kt. Amino Acids. 2002 Jun;22(4):297-308. doi: 10.1007/s007260200016. Amino Acids. 2002. PMID: 12107758

10

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.

Neres J, Bonnet P, Edwards PN, Kotian PL, Buschiazzo A, Alzari PM, Bryce RA, Douglas KT. Neres J, et al. Among authors: douglas kt. Bioorg Med Chem. 2007 Mar 1;15(5):2106-19. doi: 10.1016/j.bmc.2006.12.024. Epub 2006 Dec 15. Bioorg Med Chem. 2007. PMID: 17218104

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