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Rapamycin alleviates toxicity of different aggregate-prone proteins.
Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC. Berger Z, et al. Among authors: menzies fm. Hum Mol Genet. 2006 Feb 1;15(3):433-42. doi: 10.1093/hmg/ddi458. Epub 2005 Dec 20. Hum Mol Genet. 2006. PMID: 16368705
IGF-1 receptor antagonism inhibits autophagy.
Renna M, Bento CF, Fleming A, Menzies FM, Siddiqi FH, Ravikumar B, Puri C, Garcia-Arencibia M, Sadiq O, Corrochano S, Carter S, Brown SD, Acevedo-Arozena A, Rubinsztein DC. Renna M, et al. Among authors: menzies fm. Hum Mol Genet. 2013 Nov 15;22(22):4528-44. doi: 10.1093/hmg/ddt300. Epub 2013 Jun 25. Hum Mol Genet. 2013. PMID: 23804751 Free PMC article.
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Dami TE, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC. Jimenez-Sanchez M, et al. Nat Chem Biol. 2015 May;11(5):347-354. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6. Nat Chem Biol. 2015. PMID: 25848931 Free PMC article.
Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.
Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC. Menzies FM, et al. Cell Death Differ. 2015 Mar;22(3):433-44. doi: 10.1038/cdd.2014.151. Epub 2014 Sep 26. Cell Death Differ. 2015. PMID: 25257175 Free PMC article.
68 results