Clark K - Search Results

1

CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads.

Castanedo G, Clark K, Wang S, Tsui V, Wong M, Nicholas J, Wickramasinghe D, Marsters JC Jr, Sutherlin D. Castanedo G, et al. Among authors: clark k. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1716-20. doi: 10.1016/j.bmcl.2005.12.004. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16384702

2

Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.

Jackson DY, Quan C, Artis DR, Rawson T, Blackburn B, Struble M, Fitzgerald G, Chan K, Mullins S, Burnier JP, Fairbrother WJ, Clark K, Berisini M, Chui H, Renz M, Jones S, Fong S. Jackson DY, et al. Among authors: clark k. J Med Chem. 1997 Oct 10;40(21):3359-68. doi: 10.1021/jm970175s. J Med Chem. 1997. PMID: 9341911

3

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Gadek TR, et al. Among authors: clark kr. Science. 2002 Feb 8;295(5557):1086-9. doi: 10.1126/science.295.5557.1086. Science. 2002. PMID: 11834839

4

Selective alpha4beta7 integrin antagonists and their potential as antiinflammatory agents.

Dubree NJ, Artis DR, Castanedo G, Marsters J, Sutherlin D, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Lowman HB, Skelton NJ, Jackson DY. Dubree NJ, et al. Among authors: clark k. J Med Chem. 2002 Aug 1;45(16):3451-7. doi: 10.1021/jm020033k. J Med Chem. 2002. PMID: 12139455

5

Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.

Castanedo GM, Sailes FC, Dubree NJ, Nicholas JB, Caris L, Clark K, Keating SM, Beresini MH, Chiu H, Fong S, Marsters JC Jr, Jackson DY, Sutherlin DP. Castanedo GM, et al. Among authors: clark k. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2913-7. doi: 10.1016/s0960-894x(02)00597-8. Bioorg Med Chem Lett. 2002. PMID: 12270174

6

N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship.

Burdick DJ, Paris K, Weese K, Stanley M, Beresini M, Clark K, McDowell RS, Marsters JC, Gadek TR. Burdick DJ, et al. Among authors: clark k. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1015-8. doi: 10.1016/s0960-894x(03)00084-2. Bioorg Med Chem Lett. 2003. PMID: 12643901

7

Structure-activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors.

Ockey DA, Dotson JL, Struble ME, Stults JT, Bourell JH, Clark KR, Gadek TR. Ockey DA, et al. Bioorg Med Chem. 2004 Jan 2;12(1):37-44. doi: 10.1016/j.bmc.2003.10.053. Bioorg Med Chem. 2004. PMID: 14697768

8

N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety.

Burdick DJ, Marsters JC Jr, Aliagas-Martin I, Stanley M, Beresini M, Clark K, McDowell RS, Gadek TR. Burdick DJ, et al. Among authors: clark k. Bioorg Med Chem Lett. 2004 May 3;14(9):2055-9. doi: 10.1016/j.bmcl.2004.02.046. Bioorg Med Chem Lett. 2004. PMID: 15080978

9

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.

Keating SM, Clark KR, Stefanich LD, Arellano F, Edwards CP, Bodary SC, Spencer SA, Gadek TR, Marsters JC Jr, Beresini MH. Keating SM, et al. Protein Sci. 2006 Feb;15(2):290-303. doi: 10.1110/ps.051583406. Epub 2005 Dec 29. Protein Sci. 2006. PMID: 16384997 Free PMC article.

10

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.

Gazzard L, Appleton B, Chapman K, Chen H, Clark K, Drobnick J, Goodacre S, Halladay J, Lyssikatos J, Schmidt S, Sideris S, Wiesmann C, Williams K, Wu P, Yen I, Malek S. Gazzard L, et al. Among authors: clark k. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5704-5709. doi: 10.1016/j.bmcl.2014.10.063. Epub 2014 Oct 27. Bioorg Med Chem Lett. 2014. PMID: 25453805

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