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Placement of the vaginal 17beta-estradiol tablets in the inner or outer one third of the vagina affects the preferential delivery of 17beta-estradiol toward the uterus or periurethral areas, thereby modifying efficacy and endometrial safety.
Cicinelli E, Di Naro E, De Ziegler D, Matteo M, Morgese S, Galantino P, Brioschi PA, Schonauer A. Cicinelli E, et al. Among authors: di naro e. Am J Obstet Gynecol. 2003 Jul;189(1):55-8. doi: 10.1067/mob.2003.341. Am J Obstet Gynecol. 2003. PMID: 12861138 Clinical Trial.
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