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Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
Gauna C, Meyler FM, Janssen JA, Delhanty PJ, Abribat T, van Koetsveld P, Hofland LJ, Broglio F, Ghigo E, van der Lely AJ. Gauna C, et al. Among authors: delhanty pj. J Clin Endocrinol Metab. 2004 Oct;89(10):5035-42. doi: 10.1210/jc.2004-0363. J Clin Endocrinol Metab. 2004. PMID: 15472202 Clinical Trial.
Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.
Gauna C, Delhanty PJ, van Aken MO, Janssen JA, Themmen AP, Hofland LJ, Culler M, Broglio F, Ghigo E, van der Lely AJ. Gauna C, et al. Among authors: delhanty pj. Mol Cell Endocrinol. 2006 Jun 7;251(1-2):103-11. doi: 10.1016/j.mce.2006.03.040. Epub 2006 Apr 27. Mol Cell Endocrinol. 2006. PMID: 16647196
Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.
Gauna C, Kiewiet RM, Janssen JA, van de Zande B, Delhanty PJ, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ. Gauna C, et al. Among authors: delhanty pj. Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E697-704. doi: 10.1152/ajpendo.00219.2007. Epub 2007 Jun 19. Am J Physiol Endocrinol Metab. 2007. PMID: 17578884 Free article.
Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats.
Gauna C, Uitterlinden P, Kramer P, Kiewiet RM, Janssen JA, Delhanty PJ, van Aken MO, Ghigo E, Hofland LJ, Themmen AP, van der Lely AJ. Gauna C, et al. Among authors: delhanty pj. Endocrinology. 2007 Nov;148(11):5278-87. doi: 10.1210/en.2007-0225. Epub 2007 Aug 2. Endocrinology. 2007. PMID: 17673520
Ghrelin and bone.
van der Velde M, Delhanty P, van der Eerden B, van der Lely AJ, van Leeuwen J. van der Velde M, et al. Vitam Horm. 2008;77:239-58. doi: 10.1016/S0083-6729(06)77010-8. Vitam Horm. 2008. PMID: 17983859 Review.
90 results