Gonzales NR - Search Results

1

Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody.

Yoon SO, Lee TS, Kim SJ, Jang MH, Kang YJ, Park JH, Kim KS, Lee HS, Ryu CJ, Gonzales NR, Kashmiri SV, Lim SM, Choi CW, Hong HJ. Yoon SO, et al. Among authors: gonzales nr. J Biol Chem. 2006 Mar 17;281(11):6985-92. doi: 10.1074/jbc.M511165200. Epub 2006 Jan 9. J Biol Chem. 2006. PMID: 16407221 Free article.

2

Surface plasmon resonance-based competition assay to assess the sera reactivity of variants of humanized antibodies.

Gonzales NR, Schuck P, Schlom J, Kashmiri SV. Gonzales NR, et al. J Immunol Methods. 2002 Oct 15;268(2):197-210. doi: 10.1016/s0022-1759(02)00205-3. J Immunol Methods. 2002. PMID: 12215388

3

In vitro affinity maturation of a specificity-determining region-grafted humanized anticarcinoma antibody: isolation and characterization of minimally immunogenic high-affinity variants.

De Pascalis R, Gonzales NR, Padlan EA, Schuck P, Batra SK, Schlom J, Kashmiri SV. De Pascalis R, et al. Among authors: gonzales nr. Clin Cancer Res. 2003 Nov 15;9(15):5521-31. Clin Cancer Res. 2003. PMID: 14654532

4

Developing a minimally immunogenic humanized antibody by SDR grafting.

Kashmiri SV, De Pascalis R, Gonzales NR. Kashmiri SV, et al. Among authors: gonzales nr. Methods Mol Biol. 2004;248:361-76. doi: 10.1385/1-59259-666-5:361. Methods Mol Biol. 2004. PMID: 14970508 No abstract available.

5

Minimizing the immunogenicity of antibodies for clinical application.

Gonzales NR, De Pascalis R, Schlom J, Kashmiri SV. Gonzales NR, et al. Tumour Biol. 2005 Jan-Feb;26(1):31-43. doi: 10.1159/000084184. Tumour Biol. 2005. PMID: 15741769 Review.

6

SDR grafting--a new approach to antibody humanization.

Kashmiri SV, De Pascalis R, Gonzales NR, Schlom J. Kashmiri SV, et al. Among authors: gonzales nr. Methods. 2005 May;36(1):25-34. doi: 10.1016/j.ymeth.2005.01.003. Methods. 2005. PMID: 15848072 Review.

7

Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues.

Gonzales NR, Padlan EA, De Pascalis R, Schuck P, Schlom J, Kashmiri SV. Gonzales NR, et al. Mol Immunol. 2003 Oct;40(6):337-49. doi: 10.1016/s0161-5890(03)00166-4. Mol Immunol. 2003. PMID: 14522015

8

Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody.

De Pascalis R, Iwahashi M, Tamura M, Padlan EA, Gonzales NR, Santos AD, Giuliano M, Schuck P, Schlom J, Kashmiri SV. De Pascalis R, et al. Among authors: gonzales nr. J Immunol. 2002 Sep 15;169(6):3076-84. doi: 10.4049/jimmunol.169.6.3076. J Immunol. 2002. PMID: 12218124

9

SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity.

Gonzales NR, Padlan EA, De Pascalis R, Schuck P, Schlom J, Kashmiri SV. Gonzales NR, et al. Mol Immunol. 2004 Jul;41(9):863-72. doi: 10.1016/j.molimm.2004.03.041. Mol Immunol. 2004. PMID: 15261458

10

Combined affinity and rate constant distributions of ligand populations from experimental surface binding kinetics and equilibria.

Svitel J, Balbo A, Mariuzza RA, Gonzales NR, Schuck P. Svitel J, et al. Among authors: gonzales nr. Biophys J. 2003 Jun;84(6):4062-77. doi: 10.1016/S0006-3495(03)75132-7. Biophys J. 2003. PMID: 12770910 Free PMC article.

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