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58 results

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Page 1
Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
Young WB, Mordenti J, Torkelson S, Shrader WD, Kolesnikov A, Rai R, Liu L, Hu H, Leahy EM, Green MJ, Sprengeler PA, Katz BA, Yu C, Janc JW, Elrod KC, Marzec UM, Hanson SR. Young WB, et al. Among authors: katz ba. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2037-41. doi: 10.1016/j.bmcl.2005.12.059. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16412633
2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.
Mackman RL, Hui HC, Breitenbucher JG, Katz BA, Luong C, Martelli A, McGee D, Radika K, Sendzik M, Spencer JR, Sprengeler PA, Tario J, Verner E, Wang J. Mackman RL, et al. Among authors: katz ba. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2019-22. doi: 10.1016/s0960-894x(02)00311-6. Bioorg Med Chem Lett. 2002. PMID: 12113832
Small molecule inhibitors of plasma kallikrein.
Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. Young WB, et al. Among authors: katz ba. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2034-6. doi: 10.1016/j.bmcl.2005.12.060. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413183
Factor VIIa inhibitors: gaining selectivity within the trypsin family.
Shrader WD, Kolesnikov A, Burgess-Henry J, Rai R, Hendrix J, Hu H, Torkelson S, Ton T, Young WB, Katz BA, Yu C, Tang J, Cabuslay R, Sanford E, Janc JW, Sprengeler PA. Shrader WD, et al. Among authors: katz ba. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1596-600. doi: 10.1016/j.bmcl.2005.12.040. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413783
Factor VIIa inhibitors: improved pharmacokinetic parameters.
Kolesnikov A, Rai R, Young WB, Mordenti J, Liu L, Torkelson S, Shrader WD, Leahy EM, Hu H, Gjerstad E, Janc J, Katz BA, Sprengeler PA. Kolesnikov A, et al. Among authors: katz ba. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2243-6. doi: 10.1016/j.bmcl.2006.01.037. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455251
Discovery of novel heterocyclic factor VIIa inhibitors.
Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB. Rai R, et al. Among authors: katz ba. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2270-3. doi: 10.1016/j.bmcl.2006.01.017. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16460932
Structure-guided design of peptide-based tryptase inhibitors.
McGrath ME, Sprengeler PA, Hirschbein B, Somoza JR, Lehoux I, Janc JW, Gjerstad E, Graupe M, Estiarte A, Venkataramani C, Liu Y, Yee R, Ho JD, Green MJ, Lee CS, Liu L, Tai V, Spencer J, Sperandio D, Katz BA. McGrath ME, et al. Among authors: katz ba. Biochemistry. 2006 May 16;45(19):5964-73. doi: 10.1021/bi060173m. Biochemistry. 2006. PMID: 16681368
58 results