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Page 1
Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
Young WB, Mordenti J, Torkelson S, Shrader WD, Kolesnikov A, Rai R, Liu L, Hu H, Leahy EM, Green MJ, Sprengeler PA, Katz BA, Yu C, Janc JW, Elrod KC, Marzec UM, Hanson SR. Young WB, et al. Among authors: mordenti j. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2037-41. doi: 10.1016/j.bmcl.2005.12.059. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16412633
Small molecule inhibitors of plasma kallikrein.
Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. Young WB, et al. Among authors: mordenti j. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2034-6. doi: 10.1016/j.bmcl.2005.12.060. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413183
Factor VIIa inhibitors: improved pharmacokinetic parameters.
Kolesnikov A, Rai R, Young WB, Mordenti J, Liu L, Torkelson S, Shrader WD, Leahy EM, Hu H, Gjerstad E, Janc J, Katz BA, Sprengeler PA. Kolesnikov A, et al. Among authors: mordenti j. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2243-6. doi: 10.1016/j.bmcl.2006.01.037. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455251
Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability.
Riggs JR, Kolesnikov A, Hendrix J, Young WB, Shrader WD, Vijaykumar D, Stephens R, Liu L, Pan L, Mordenti J, Green MJ, Sukbuntherng J. Riggs JR, et al. Among authors: mordenti j. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2224-8. doi: 10.1016/j.bmcl.2006.01.039. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458507
Identification of metabolites of the tryptase inhibitor CRA-9249: observation of a metabolite derived from an unexpected hydroxylation pathway.
Yu W, Dener JM, Dickman DA, Grothaus P, Ling Y, Liu L, Havel C, Malesky K, Mahajan T, O'Brian C, Shelton EJ, Sperandio D, Tong Z, Yee R, Mordenti JJ. Yu W, et al. Among authors: mordenti jj. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4053-8. doi: 10.1016/j.bmcl.2006.05.003. Epub 2006 May 18. Bioorg Med Chem Lett. 2006. PMID: 16713261
55 results