Jin Y - Search Results

1

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.

Penning TM, Steckelbroeck S, Bauman DR, Miller MW, Jin Y, Peehl DM, Fung KM, Lin HK. Penning TM, et al. Among authors: jin y. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):182-91. doi: 10.1016/j.mce.2005.12.009. Epub 2006 Jan 18. Mol Cell Endocrinol. 2006. PMID: 16417966

2

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.

Steckelbroeck S, Jin Y, Oyesanmi B, Kloosterboer HJ, Penning TM. Steckelbroeck S, et al. Among authors: jin y. Mol Pharmacol. 2004 Dec;66(6):1702-11. doi: 10.1124/mol.104.004515. Epub 2004 Sep 21. Mol Pharmacol. 2004. PMID: 15383625

3

Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes.

Bauman DR, Rudnick SI, Szewczuk LM, Jin Y, Gopishetty S, Penning TM. Bauman DR, et al. Among authors: jin y. Mol Pharmacol. 2005 Jan;67(1):60-8. doi: 10.1124/mol.104.006569. Epub 2004 Oct 8. Mol Pharmacol. 2005. PMID: 15475569

4

Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.

Steckelbroeck S, Oyesanmi B, Jin Y, Lee SH, Kloosterboer HJ, Penning TM. Steckelbroeck S, et al. Among authors: jin y. J Pharmacol Exp Ther. 2006 Mar;316(3):1300-9. doi: 10.1124/jpet.105.091587. Epub 2005 Dec 8. J Pharmacol Exp Ther. 2006. PMID: 16339391

5

Aldo-keto reductases and bioactivation/detoxication.

Jin Y, Penning TM. Jin Y, et al. Annu Rev Pharmacol Toxicol. 2007;47:263-92. doi: 10.1146/annurev.pharmtox.47.120505.105337. Annu Rev Pharmacol Toxicol. 2007. PMID: 16970545 Review.

6

Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor.

Penning TM, Bauman DR, Jin Y, Rizner TL. Penning TM, et al. Among authors: jin y. Mol Cell Endocrinol. 2007 Feb;265-266:77-82. doi: 10.1016/j.mce.2006.12.007. Epub 2007 Jan 16. Mol Cell Endocrinol. 2007. PMID: 17223255 Free PMC article. Review.

7

Pre-receptor regulation of the androgen receptor.

Penning TM, Jin Y, Rizner TL, Bauman DR. Penning TM, et al. Among authors: jin y. Mol Cell Endocrinol. 2008 Jan 16;281(1-2):1-8. doi: 10.1016/j.mce.2007.10.008. Epub 2007 Oct 22. Mol Cell Endocrinol. 2008. PMID: 18060684 Free PMC article. Review.

8

Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.

Byrns MC, Jin Y, Penning TM. Byrns MC, et al. Among authors: jin y. J Steroid Biochem Mol Biol. 2011 May;125(1-2):95-104. doi: 10.1016/j.jsbmb.2010.11.004. Epub 2010 Nov 16. J Steroid Biochem Mol Biol. 2011. PMID: 21087665 Free PMC article. Review.

9

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

Jin Y, Mesaros AC, Blair IA, Penning TM. Jin Y, et al. Biochem J. 2011 Jul 1;437(1):53-61. doi: 10.1042/BJ20101804. Biochem J. 2011. PMID: 21521174 Free PMC article.

10

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily.

Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. Jin Y, et al. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):139-44. doi: 10.1016/j.jsbmb.2011.12.002. Epub 2011 Dec 28. J Steroid Biochem Mol Biol. 2012. PMID: 22210085 Free PMC article.

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