Hegan DC - Search Results

1

Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).

Smith-Roe SL, Löhr CV, Bildfell RJ, Fischer KA, Hegan DC, Glazer PM, Buermeyer AB. Smith-Roe SL, et al. Among authors: hegan dc. Cancer Lett. 2006 Nov 28;244(1):79-85. doi: 10.1016/j.canlet.2005.12.002. Epub 2006 Jan 20. Cancer Lett. 2006. PMID: 16427736

2

Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP).

Smith-Roe SL, Hegan DC, Glazer PM, Buermeyer AB. Smith-Roe SL, et al. Among authors: hegan dc. Mutat Res. 2006 Feb 22;594(1-2):101-12. doi: 10.1016/j.mrfmmm.2005.08.011. Epub 2005 Oct 26. Mutat Res. 2006. PMID: 16256150

3

Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance.

Gibson SL, Narayanan L, Hegan DC, Buermeyer AB, Liskay RM, Glazer PM. Gibson SL, et al. Among authors: hegan dc. Cancer Lett. 2006 Dec 8;244(2):195-202. doi: 10.1016/j.canlet.2005.12.009. Epub 2006 Jan 19. Cancer Lett. 2006. PMID: 16426742

4

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.

Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM. Hegan DC, et al. Carcinogenesis. 2006 Dec;27(12):2402-8. doi: 10.1093/carcin/bgl079. Epub 2006 May 25. Carcinogenesis. 2006. PMID: 16728433 Free PMC article.

5

Hypoxia and DNA repair.

Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE. Glazer PM, et al. Among authors: hegan dc. Yale J Biol Med. 2013 Dec 13;86(4):443-51. Yale J Biol Med. 2013. PMID: 24348208 Free PMC article.

6

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells.

Scanlon SE, Scanlon CD, Hegan DC, Sulkowski PL, Glazer PM. Scanlon SE, et al. Among authors: hegan dc. Carcinogenesis. 2017 Jun 1;38(6):627-637. doi: 10.1093/carcin/bgx038. Carcinogenesis. 2017. PMID: 28472268 Free PMC article.

7

Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.

Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB. Colis LC, et al. Among authors: hegan dc. J Am Chem Soc. 2015 May 6;137(17):5741-7. doi: 10.1021/ja513117p. Epub 2015 Apr 22. J Am Chem Soc. 2015. PMID: 25849366 Free PMC article.

8

Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma.

Scanlon SE, Hegan DC, Sulkowski PL, Glazer PM. Scanlon SE, et al. Among authors: hegan dc. Oncotarget. 2017 Dec 19;9(4):4647-4660. doi: 10.18632/oncotarget.23470. eCollection 2018 Jan 12. Oncotarget. 2017. PMID: 29435132 Free PMC article.

9

The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.

Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB. Colis LC, et al. Among authors: hegan dc. Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11. Nat Chem. 2014. PMID: 24848236 Free PMC article.

10

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM. Hegan DC, et al. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2201-6. doi: 10.1073/pnas.0904783107. Epub 2010 Jan 19. Proc Natl Acad Sci U S A. 2010. PMID: 20133863 Free PMC article.

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