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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.
Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, MacGregor L, Kiers L, Cherny R, Li QX, Tammer A, Carrington D, Mavros C, Volitakis I, Xilinas M, Ames D, Davis S, Beyreuther K, Tanzi RE, Masters CL. Ritchie CW, et al. Arch Neurol. 2003 Dec;60(12):1685-91. doi: 10.1001/archneur.60.12.1685. Arch Neurol. 2003. PMID: 14676042 Clinical Trial.
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
White AR, Du T, Laughton KM, Volitakis I, Sharples RA, Xilinas ME, Hoke DE, Holsinger RM, Evin G, Cherny RA, Hill AF, Barnham KJ, Li QX, Bush AI, Masters CL. White AR, et al. Among authors: cherny ra. J Biol Chem. 2006 Jun 30;281(26):17670-80. doi: 10.1074/jbc.M602487200. Epub 2006 Apr 28. J Biol Chem. 2006. PMID: 16648635 Free article.
Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide.
Donnelly PS, Caragounis A, Du T, Laughton KM, Volitakis I, Cherny RA, Sharples RA, Hill AF, Li QX, Masters CL, Barnham KJ, White AR. Donnelly PS, et al. Among authors: cherny ra. J Biol Chem. 2008 Feb 22;283(8):4568-77. doi: 10.1074/jbc.M705957200. Epub 2007 Dec 17. J Biol Chem. 2008. PMID: 18086681 Free article.
92 results