Henne KR - Search Results

1

The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism.

Fisher MB, Henne KR, Boer J. Fisher MB, et al. Among authors: henne kr. Curr Opin Drug Discov Devel. 2006 Jan;9(1):101-9. Curr Opin Drug Discov Devel. 2006. PMID: 16445122 Review.

2

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP. Kalgutkar AS, et al. Among authors: henne kr. Curr Drug Metab. 2005 Jun;6(3):161-225. doi: 10.2174/1389200054021799. Curr Drug Metab. 2005. PMID: 15975040 Review.

3

Active site characteristics of CYP4B1 probed with aromatic ligands.

Henne KR, Fisher MB, Iyer KR, Lang DH, Trager WF, Rettie AE. Henne KR, et al. Biochemistry. 2001 Jul 24;40(29):8597-605. doi: 10.1021/bi010395e. Biochemistry. 2001. PMID: 11456500

4

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.

Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE. Haining RL, et al. Among authors: henne kr. Biochemistry. 1999 Mar 16;38(11):3285-92. doi: 10.1021/bi982161+. Biochemistry. 1999. PMID: 10079071

5

Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.

Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA. Kalgutkar AS, et al. Among authors: henne kr. Biopharm Drug Dispos. 2006 Nov;27(8):371-86. doi: 10.1002/bdd.520. Biopharm Drug Dispos. 2006. PMID: 16944451

6

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.

Kalgutkar AS, Vaz AD, Lame ME, Henne KR, Soglia J, Zhao SX, Abramov YA, Lombardo F, Collin C, Hendsch ZS, Hop CE. Kalgutkar AS, et al. Among authors: henne kr. Drug Metab Dispos. 2005 Feb;33(2):243-53. doi: 10.1124/dmd.104.001735. Epub 2004 Nov 2. Drug Metab Dispos. 2005. PMID: 15523046

7

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4.

Kalgutkar AS, Henne KR, Lame ME, Vaz AD, Collin C, Soglia JR, Zhao SX, Hop CE. Kalgutkar AS, et al. Among authors: henne kr. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20. doi: 10.1016/j.cbi.2005.03.036. Epub 2005 Apr 18. Chem Biol Interact. 2005. PMID: 15978881

8

Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate.

Zheng YM, Baer BR, Kneller MB, Henne KR, Kunze KL, Rettie AE. Zheng YM, et al. Among authors: henne kr. Biochemistry. 2003 Apr 22;42(15):4601-6. doi: 10.1021/bi020667t. Biochemistry. 2003. PMID: 12693958

9

Genetic association between sensitivity to warfarin and expression of CYP2C9*3.

Steward DJ, Haining RL, Henne KR, Davis G, Rushmore TH, Trager WF, Rettie AE. Steward DJ, et al. Among authors: henne kr. Pharmacogenetics. 1997 Oct;7(5):361-7. doi: 10.1097/00008571-199710000-00004. Pharmacogenetics. 1997. PMID: 9352571

10

Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.

Henne KR, Gaedigk A, Gupta G, Leeder JS, Rettie AE. Henne KR, et al. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):143-8. doi: 10.1016/s0378-4347(98)00099-1. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9686881

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