Leppla SH - Search Results

1

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Molloy SS, Bresnahan PA, Leppla SH, Klimpel KR, Thomas G. Molloy SS, et al. Among authors: leppla sh. J Biol Chem. 1992 Aug 15;267(23):16396-402. J Biol Chem. 1992. PMID: 1644824 Free article.

2

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Klimpel KR, Molloy SS, Thomas G, Leppla SH. Klimpel KR, et al. Among authors: leppla sh. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10277-81. doi: 10.1073/pnas.89.21.10277. Proc Natl Acad Sci U S A. 1992. PMID: 1438214 Free PMC article.

3

Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells.

Arora N, Klimpel KR, Singh Y, Leppla SH. Arora N, et al. Among authors: leppla sh. J Biol Chem. 1992 Aug 5;267(22):15542-8. J Biol Chem. 1992. PMID: 1639793 Free article.

4

The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity.

Singh Y, Klimpel KR, Quinn CP, Chaudhary VK, Leppla SH. Singh Y, et al. Among authors: leppla sh. J Biol Chem. 1991 Aug 15;266(23):15493-7. J Biol Chem. 1991. PMID: 1651334 Free article.

5

Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis.

Quinn CP, Singh Y, Klimpel KR, Leppla SH. Quinn CP, et al. Among authors: leppla sh. J Biol Chem. 1991 Oct 25;266(30):20124-30. J Biol Chem. 1991. PMID: 1939073 Free article.

6

The chymotrypsin-sensitive site, FFD315, in anthrax toxin protective antigen is required for translocation of lethal factor.

Singh Y, Klimpel KR, Arora N, Sharma M, Leppla SH. Singh Y, et al. Among authors: leppla sh. J Biol Chem. 1994 Nov 18;269(46):29039-46. J Biol Chem. 1994. PMID: 7961869 Free article.

7

In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes.

Friedman TC, Gordon VM, Leppla SH, Klimpel KR, Birch NP, Loh YP. Friedman TC, et al. Among authors: leppla sh. Arch Biochem Biophys. 1995 Jan 10;316(1):5-13. doi: 10.1006/abbi.1995.1002. Arch Biochem Biophys. 1995. PMID: 7840657

8

Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.

Klimpel KR, Arora N, Leppla SH. Klimpel KR, et al. Among authors: leppla sh. Mol Microbiol. 1994 Sep;13(6):1093-100. doi: 10.1111/j.1365-2958.1994.tb00500.x. Mol Microbiol. 1994. PMID: 7854123

9

Crystal structure of the anthrax toxin protective antigen.

Petosa C, Collier RJ, Klimpel KR, Leppla SH, Liddington RC. Petosa C, et al. Among authors: leppla sh. Nature. 1997 Feb 27;385(6619):833-8. doi: 10.1038/385833a0. Nature. 1997. PMID: 9039918

10

The pore-forming toxin proaerolysin is activated by furin.

Abrami L, Fivaz M, Decroly E, Seidah NG, Jean F, Thomas G, Leppla SH, Buckley JT, van der Goot FG. Abrami L, et al. Among authors: leppla sh. J Biol Chem. 1998 Dec 4;273(49):32656-61. doi: 10.1074/jbc.273.49.32656. J Biol Chem. 1998. PMID: 9830006 Free article.

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