Szakacs G - Search Results

1

Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance.

Fang L, Zhang G, Li C, Zheng X, Zhu L, Xiao JJ, Szakacs G, Nadas J, Chan KK, Wang PG, Sun D. Fang L, et al. Among authors: szakacs g. J Med Chem. 2006 Feb 9;49(3):932-41. doi: 10.1021/jm050800q. J Med Chem. 2006. PMID: 16451059

2

Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.

Hall MD, Salam NK, Hellawell JL, Fales HM, Kensler CB, Ludwig JA, Szakács G, Hibbs DE, Gottesman MM. Hall MD, et al. Among authors: szakacs g. J Med Chem. 2009 May 28;52(10):3191-204. doi: 10.1021/jm800861c. J Med Chem. 2009. PMID: 19397322 Free PMC article.

3

Structure-activity relationships of chromone derivatives toward the mechanism of interaction with and inhibition of breast cancer resistance protein ABCG2.

Winter E, Lecerf-Schmidt F, Gozzi G, Peres B, Lightbody M, Gauthier C, Ozvegy-Laczka C, Szakacs G, Sarkadi B, Creczynski-Pasa TB, Boumendjel A, Di Pietro A. Winter E, et al. Among authors: szakacs g. J Med Chem. 2013 Dec 27;56(24):9849-60. doi: 10.1021/jm401649j. Epub 2013 Dec 13. J Med Chem. 2013. PMID: 24304387

4

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance.

Pape VF, Tóth S, Füredi A, Szebényi K, Lovrics A, Szabó P, Wiese M, Szakács G. Pape VF, et al. Among authors: szakacs g. Eur J Med Chem. 2016 Jul 19;117:335-54. doi: 10.1016/j.ejmech.2016.03.078. Epub 2016 Mar 30. Eur J Med Chem. 2016. PMID: 27161177

5

Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines.

Pósa SP, Dargó G, Nagy S, Kisszékelyi P, Garádi Z, Hámori L, Szakács G, Kupai J, Tóth S. Pósa SP, et al. Among authors: szakacs g. Bioorg Med Chem. 2022 Aug 1;67:116855. doi: 10.1016/j.bmc.2022.116855. Epub 2022 May 26. Bioorg Med Chem. 2022. PMID: 35640378 Free article.

6

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters.

Dankó B, Tóth S, Martins A, Vágvölgyi M, Kúsz N, Molnár J, Chang FR, Wu YC, Szakács G, Hunyadi A. Dankó B, et al. Among authors: szakacs g. ChemMedChem. 2017 Jun 7;12(11):850-859. doi: 10.1002/cmdc.201700225. Epub 2017 May 23. ChemMedChem. 2017. PMID: 28436164

7

Structure-Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer.

Pape VFS, Palkó R, Tóth S, Szabó MJ, Sessler J, Dormán G, Enyedy ÉA, Soós T, Szatmári I, Szakács G. Pape VFS, et al. Among authors: szakacs g. J Med Chem. 2022 Jun 9;65(11):7729-7745. doi: 10.1021/acs.jmedchem.2c00076. Epub 2022 May 25. J Med Chem. 2022. PMID: 35613553 Free PMC article.

8

Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters.

Milunovic MNM, Ohui K, Besleaga I, Petrasheuskaya TV, Dömötör O, Enyedy ÉA, Darvasiova D, Rapta P, Barbieriková Z, Vegh D, Tóth S, Tóth J, Kucsma N, Szakács G, Popović-Bijelić A, Zafar A, Reynisson J, Shutalev AD, Bai R, Hamel E, Arion VB. Milunovic MNM, et al. Among authors: szakacs g. J Med Chem. 2024 Jun 13;67(11):9069-9090. doi: 10.1021/acs.jmedchem.4c00259. Epub 2024 May 21. J Med Chem. 2024. PMID: 38771959 Free PMC article.

9

MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.

Smith AJ, van Helvoort A, van Meer G, Szabo K, Welker E, Szakacs G, Varadi A, Sarkadi B, Borst P. Smith AJ, et al. Among authors: szakacs g. J Biol Chem. 2000 Aug 4;275(31):23530-9. doi: 10.1074/jbc.M909002199. J Biol Chem. 2000. PMID: 10918072 Free article.

10

Targeting multidrug resistance in cancer.

Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM. Szakács G, et al. Nat Rev Drug Discov. 2006 Mar;5(3):219-34. doi: 10.1038/nrd1984. Nat Rev Drug Discov. 2006. PMID: 16518375 Review.

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