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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity.
Piovesan D, Tan JBL, Becker A, Banuelos J, Narasappa N, DiRenzo D, Zhang K, Chen A, Ginn E, Udyavar AR, Yin F, Paprcka SL, Purandare B, Park TW, Kimura N, Kalisiak J, Young SW, Powers JP, Schindler U, Sivick KE, Walters MJ. Piovesan D, et al. Among authors: powers jp. Mol Cancer Ther. 2022 Jun 1;21(6):948-959. doi: 10.1158/1535-7163.MCT-21-0802. Mol Cancer Ther. 2022. PMID: 35405741 Free PMC article.
Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ).
Mata G, Miles DH, Drew SL, Fournier J, Lawson KV, Mailyan AK, Sharif EU, Yan X, Beatty JW, Banuelos J, Chen J, Ginn E, Chen A, Gerrick KY, Pham AT, Wong K, Soni D, Dhanota P, Shaqfeh SG, Meleza C, Narasappa N, Singh H, Zhao X, Jin L, Schindler U, Walters MJ, Young SW, Walker NP, Leleti MR, Powers JP, Jeffrey JL. Mata G, et al. Among authors: powers jp. J Med Chem. 2022 Jan 27;65(2):1418-1444. doi: 10.1021/acs.jmedchem.1c01153. Epub 2021 Oct 21. J Med Chem. 2022. PMID: 34672584
Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.
Sharif EU, Kalisiak J, Lawson KV, Miles DH, Newcomb E, Lindsey EA, Rosen BR, Debien LPP, Chen A, Zhao X, Young SW, Walker NP, Sträter N, Scaletti ER, Jin L, Xu G, Leleti MR, Powers JP. Sharif EU, et al. Among authors: powers jp. J Med Chem. 2021 Jan 14;64(1):845-860. doi: 10.1021/acs.jmedchem.0c01835. Epub 2021 Jan 5. J Med Chem. 2021. PMID: 33399453
61 results