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A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae.
Uehara T, Zulli AL, Miller B, Avery LM, Boyd SA, Chatwin CL, Chu GH, Drager AS, Edwards M, Emeigh Hart SG, Myers CL, Rongala G, Stevenson A, Uehara K, Yi F, Wang B, Liu Z, Wang M, Zhao Z, Zhou X, Zhao H, Stratton CM, Bala S, Davies C, Tkavc R, Jerse AE, Pevear DC, Burns CJ, Daigle DM, Condon SM. Uehara T, et al. Among authors: pevear dc. bioRxiv [Preprint]. 2024 Dec 27:2024.12.27.630553. doi: 10.1101/2024.12.27.630553. bioRxiv. 2024. PMID: 39763734 Free PMC article. Preprint.
In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program.
Karlowsky JA, Hackel MA, Wise MG, Six DA, Uehara T, Daigle DM, Cusick SM, Pevear DC, Moeck G, Sahm DF. Karlowsky JA, et al. Among authors: pevear dc. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0128122. doi: 10.1128/aac.01281-22. Epub 2022 Dec 21. Antimicrob Agents Chemother. 2023. PMID: 36541767 Free PMC article.
Biographical Feature: Marc S. Collett (23 May 1951-11 June 2022): the Battle against Viral Disease Has Lost a Valiant Warrior, and the World Has Lost a Splendid Human Being.
Glassman KF, Brugge JS, Purchio AF, Kakach LT, Fuerst TR, Woods RM, Stover CK, Chunduru SK, Hincks JR, McKinlay MA, Nash CH, Pevear DC, Monath TP, Rice CM, Peters P. Glassman KF, et al. Among authors: pevear dc. J Virol. 2023 Jan 31;97(1):e0164322. doi: 10.1128/jvi.01643-22. Epub 2022 Dec 5. J Virol. 2023. PMID: 36468860 Free PMC article. No abstract available.
Ceftibuten-Ledaborbactam Activity against Multidrug-Resistant and Extended-Spectrum-β-Lactamase-Positive Clinical Isolates of Enterobacterales from a 2018-2020 Global Surveillance Collection.
Karlowsky JA, Wise MG, Hackel MA, Pevear DC, Moeck G, Sahm DF. Karlowsky JA, et al. Among authors: pevear dc. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0093422. doi: 10.1128/aac.00934-22. Epub 2022 Oct 26. Antimicrob Agents Chemother. 2022. PMID: 36286518 Free PMC article.
Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes.
Trout RE, Zulli A, Mesaros E, Jackson RW, Boyd S, Liu B, Hamrick J, Daigle D, Chatwin CL, John K, McLaughlin L, Cusick SM, Weiss WJ, Pulse ME, Pevear DC, Moeck G, Xerri L, Burns CJ. Trout RE, et al. Among authors: pevear dc. J Med Chem. 2021 Jul 22;64(14):10155-10166. doi: 10.1021/acs.jmedchem.1c00437. Epub 2021 Jun 30. J Med Chem. 2021. PMID: 34191513 Free PMC article.
Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases.
Chatwin CL, Hamrick JC, Trout REL, Myers CL, Cusick SM, Weiss WJ, Pulse ME, Xerri L, Burns CJ, Moeck G, Daigle DM, John K, Uehara T, Pevear DC. Chatwin CL, et al. Among authors: pevear dc. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0055221. doi: 10.1128/AAC.00552-21. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 34001510 Free PMC article.
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa.
Hamrick JC, Docquier JD, Uehara T, Myers CL, Six DA, Chatwin CL, John KJ, Vernacchio SF, Cusick SM, Trout REL, Pozzi C, De Luca F, Benvenuti M, Mangani S, Liu B, Jackson RW, Moeck G, Xerri L, Burns CJ, Pevear DC, Daigle DM. Hamrick JC, et al. Among authors: pevear dc. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01963-19. doi: 10.1128/AAC.01963-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31871094 Free PMC article.
69 results