Spaltenstein A - Search Results

1

Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.

Miller JF, Andrews CW, Brieger M, Furfine ES, Hale MR, Hanlon MH, Hazen RJ, Kaldor I, McLean EW, Reynolds D, Sammond DM, Spaltenstein A, Tung R, Turner EM, Xu RX, Sherrill RG. Miller JF, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1788-94. doi: 10.1016/j.bmcl.2006.01.035. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458505

2

Novel spirocyclic pyrrolidones as P2/P1 mimetics in potent inhibitors of HIV-1 protease.

Kazmierski WM, Furfine E, Spaltenstein A, Wright LL. Kazmierski WM, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3431-3. doi: 10.1016/s0960-894x(02)00733-3. Bioorg Med Chem Lett. 2002. PMID: 12419377

3

Novel prodrug approach to amprenavir-based HIV-1 protease inhibitors via O-->N acyloxy migration of P1 moiety.

Kazmierski WM, Bevans P, Furfine E, Spaltenstein A, Yang H. Kazmierski WM, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2523-6. doi: 10.1016/s0960-894x(03)00463-3. Bioorg Med Chem Lett. 2003. PMID: 12852957

4

Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains.

Miller JF, Furfine ES, Hanlon MH, Hazen RJ, Ray JA, Robinson L, Samano V, Spaltenstein A. Miller JF, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2004 Feb 23;14(4):959-63. doi: 10.1016/j.bmcl.2003.12.008. Bioorg Med Chem Lett. 2004. PMID: 15013001

5

Potent inhibitors of the HIV-1 protease incorporating cyclic urea P1-P2 scaffold.

Kazmierski WM, Furfine E, Gray-Nunez Y, Spaltenstein A, Wright L. Kazmierski WM, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5685-7. doi: 10.1016/j.bmcl.2004.08.038. Bioorg Med Chem Lett. 2004. PMID: 15482948

6

Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties.

Kazmierski WM, Andrews W, Furfine E, Spaltenstein A, Wright L. Kazmierski WM, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5689-92. doi: 10.1016/j.bmcl.2004.08.039. Bioorg Med Chem Lett. 2004. PMID: 15482949

7

Inhibition of wild-type and mutant human immunodeficiency virus type 1 proteases by GW0385 and other arylsulfonamides.

Hanlon MH, Porter DJ, Furfine ES, Spaltenstein A, Carter HL, Danger D, Shu AY, Kaldor IW, Miller JF, Samano VA. Hanlon MH, et al. Among authors: spaltenstein a. Biochemistry. 2004 Nov 16;43(45):14500-7. doi: 10.1021/bi0488799. Biochemistry. 2004. PMID: 15533054

8

Optimization of pyrrolidinone based HIV protease inhibitors.

Sherrill RG, Andrews CW, Bock WJ, Davis-Ward RG, Furfine ES, Hazen RJ, Rutkowske RD, Spaltenstein A, Wright LL. Sherrill RG, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2005 Jan 3;15(1):81-4. doi: 10.1016/j.bmcl.2004.10.029. Bioorg Med Chem Lett. 2005. PMID: 15582415

9

Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors.

Sherrill RG, Furfine ES, Hazen RJ, Miller JF, Reynolds DJ, Sammond DM, Spaltenstein A, Wheelan P, Wright LL. Sherrill RG, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3560-4. doi: 10.1016/j.bmcl.2005.05.101. Bioorg Med Chem Lett. 2005. PMID: 15975788

10

Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.

Miller JF, Brieger M, Furfine ES, Hazen RJ, Kaldor I, Reynolds D, Sherrill RG, Spaltenstein A. Miller JF, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3496-500. doi: 10.1016/j.bmcl.2005.05.129. Bioorg Med Chem Lett. 2005. PMID: 15990305

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