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Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist.
Vanover KE, Weiner DM, Makhay M, Veinbergs I, Gardell LR, Lameh J, Del Tredici AL, Piu F, Schiffer HH, Ott TR, Burstein ES, Uldam AK, Thygesen MB, Schlienger N, Andersson CM, Son TY, Harvey SC, Powell SB, Geyer MA, Tolf BR, Brann MR, Davis RE. Vanover KE, et al. Among authors: thygesen mb. J Pharmacol Exp Ther. 2006 May;317(2):910-8. doi: 10.1124/jpet.105.097006. Epub 2006 Feb 9. J Pharmacol Exp Ther. 2006. PMID: 16469866
Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.
Bech EM, Martos-Maldonado MC, Wismann P, Sørensen KK, van Witteloostuijn SB, Thygesen MB, Vrang N, Jelsing J, Pedersen SL, Jensen KJ. Bech EM, et al. Among authors: thygesen mb. J Med Chem. 2017 Sep 14;60(17):7434-7446. doi: 10.1021/acs.jmedchem.7b00787. Epub 2017 Aug 16. J Med Chem. 2017. PMID: 28771355
Neoglycolipids for Prolonging the Effects of Peptides: Self-Assembling Glucagon-like Peptide 1 Analogues with Albumin Binding Properties and Potent in Vivo Efficacy.
van Witteloostuijn SB, Mannerstedt K, Wismann P, Bech EM, Thygesen MB, Vrang N, Jelsing J, Jensen KJ, Pedersen SL. van Witteloostuijn SB, et al. Among authors: thygesen mb. Mol Pharm. 2017 Jan 3;14(1):193-205. doi: 10.1021/acs.molpharmaceut.6b00787. Epub 2016 Dec 22. Mol Pharm. 2017. PMID: 28005376
Selective Acylation of Proteins at Gly and Lys in His Tags.
Jensen KJ, Thygesen MB, Sørensen KK, Wu S, Treiberg T, Schoffelen S. Jensen KJ, et al. Among authors: thygesen mb. Chembiochem. 2022 Dec 16;23(24):e202200359. doi: 10.1002/cbic.202200359. Epub 2022 Sep 14. Chembiochem. 2022. PMID: 35984670
Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence.
Martos-Maldonado MC, Hjuler CT, Sørensen KK, Thygesen MB, Rasmussen JE, Villadsen K, Midtgaard SR, Kol S, Schoffelen S, Jensen KJ. Martos-Maldonado MC, et al. Among authors: thygesen mb. Nat Commun. 2018 Aug 17;9(1):3307. doi: 10.1038/s41467-018-05695-3. Nat Commun. 2018. PMID: 30120230 Free PMC article.
44 results