Lewitzky M - Search Results

1

Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors.

Feller SM, Lewitzky M. Feller SM, et al. Among authors: lewitzky m. Curr Pharm Des. 2006;12(5):529-48. doi: 10.2174/138161206775474369. Curr Pharm Des. 2006. PMID: 16472145 Review.

2

Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76.

Harkiolaki M, Lewitzky M, Gilbert RJ, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM. Harkiolaki M, et al. Among authors: lewitzky m. EMBO J. 2003 Jun 2;22(11):2571-82. doi: 10.1093/emboj/cdg258. EMBO J. 2003. PMID: 12773374 Free PMC article.

3

Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix.

Lewitzky M, Harkiolaki M, Domart MC, Jones EY, Feller SM. Lewitzky M, et al. J Biol Chem. 2004 Jul 2;279(27):28724-32. doi: 10.1074/jbc.M402745200. Epub 2004 Apr 20. J Biol Chem. 2004. PMID: 15100220 Free article.

4

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases.

Feller SM, Wecklein H, Lewitzky M, Kibler E, Raabe T. Feller SM, et al. Among authors: lewitzky m. Mech Dev. 2002 Aug;116(1-2):129-39. doi: 10.1016/s0925-4773(02)00147-8. Mech Dev. 2002. PMID: 12128212 Free article.

5

Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.

Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM. Harkiolaki M, et al. Among authors: lewitzky m. Structure. 2009 Jun 10;17(6):809-22. doi: 10.1016/j.str.2009.03.017. Structure. 2009. PMID: 19523899 Free article.

6

Very 'sticky' proteins - not too sticky after all?

Feller SM, Lewitzky M. Feller SM, et al. Among authors: lewitzky m. Cell Commun Signal. 2012 Jun 14;10(1):15. doi: 10.1186/1478-811X-10-15. Cell Commun Signal. 2012. PMID: 22697256 Free PMC article.

7

Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks.

Lewitzky M, Simister PC, Feller SM. Lewitzky M, et al. FEBS Lett. 2012 Aug 14;586(17):2740-50. doi: 10.1016/j.febslet.2012.04.029. Epub 2012 Apr 25. FEBS Lett. 2012. PMID: 22710161 Free article. Review.

8

What's in a loop?

Feller SM, Lewitzky M. Feller SM, et al. Among authors: lewitzky m. Cell Commun Signal. 2012 Oct 30;10(1):31. doi: 10.1186/1478-811X-10-31. Cell Commun Signal. 2012. PMID: 23110718 Free PMC article.

9

Conformational recognition of an intrinsically disordered protein.

Krieger JM, Fusco G, Lewitzky M, Simister PC, Marchant J, Camilloni C, Feller SM, De Simone A. Krieger JM, et al. Among authors: lewitzky m. Biophys J. 2014 Apr 15;106(8):1771-9. doi: 10.1016/j.bpj.2014.03.004. Biophys J. 2014. PMID: 24739176 Free PMC article.

10

The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.

Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM. Lewitzky M, et al. Oncogene. 2001 Mar 1;20(9):1052-62. doi: 10.1038/sj.onc.1204202. Oncogene. 2001. PMID: 11314042

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