Koch U - Search Results

1

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F. Koch U, et al. J Med Chem. 2006 Mar 9;49(5):1693-705. doi: 10.1021/jm051064t. J Med Chem. 2006. PMID: 16509585

2

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

Narjes F, Koehler KF, Koch U, Gerlach B, Colarusso S, Steinkühler C, Brunetti M, Altamura S, De Francesco R, Matassa VG. Narjes F, et al. Among authors: koch u. Bioorg Med Chem Lett. 2002 Feb 25;12(4):701-4. doi: 10.1016/s0960-894x(01)00842-3. Bioorg Med Chem Lett. 2002. PMID: 11844705

3

Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease.

Colarusso S, Gerlach B, Koch U, Muraglia E, Conte I, Stansfield I, Matassa VG, Narjes F. Colarusso S, et al. Among authors: koch u. Bioorg Med Chem Lett. 2002 Feb 25;12(4):705-8. doi: 10.1016/s0960-894x(01)00843-5. Bioorg Med Chem Lett. 2002. PMID: 11844706

4

Capped dipeptide alpha-ketoacid inhibitors of the HCV NS3 protease.

Nizi E, Koch U, Ponzi S, Matassa VG, Gardelli C. Nizi E, et al. Among authors: koch u. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3325-8. doi: 10.1016/s0960-894x(02)00691-1. Bioorg Med Chem Lett. 2002. PMID: 12392743

5

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.

Colarusso S, Koch U, Gerlach B, Steinkühler C, De Francesco R, Altamura S, Matassa VG, Narjes F. Colarusso S, et al. Among authors: koch u. J Med Chem. 2003 Jan 30;46(3):345-8. doi: 10.1021/jm025594q. J Med Chem. 2003. PMID: 12540231

6

Recent developments in the discovery of hepatitis C virus serine protease inhibitors--towards a new class of antiviral agents?

Narjes F, Koch U, Steinkühler C. Narjes F, et al. Among authors: koch u. Expert Opin Investig Drugs. 2003 Feb;12(2):153-63. doi: 10.1517/13543784.12.2.153. Expert Opin Investig Drugs. 2003. PMID: 12556211 Review.

7

Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures.

Orvieto F, Koch U, Matassa VG, Muraglia E. Orvieto F, et al. Among authors: koch u. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2745-8. doi: 10.1016/s0960-894x(03)00536-5. Bioorg Med Chem Lett. 2003. PMID: 12873506

8

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. Among authors: koch u. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

9

Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease.

Nizi E, Koch U, Ontoria JM, Marchetti A, Narjes F, Malancona S, Matassa VG, Gardelli C. Nizi E, et al. Among authors: koch u. Bioorg Med Chem Lett. 2004 May 3;14(9):2151-4. doi: 10.1016/j.bmcl.2004.02.032. Bioorg Med Chem Lett. 2004. PMID: 15080998

10

The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.

Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkühler C, Volpari C, Harper S. Ontoria JM, et al. Among authors: koch u. J Med Chem. 2004 Dec 16;47(26):6443-6. doi: 10.1021/jm049435d. J Med Chem. 2004. PMID: 15588076

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