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Prelamin A and lamin A appear to be dispensable in the nuclear lamina.
Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. Fong LG, et al. Among authors: bennett cf. J Clin Invest. 2006 Mar;116(3):743-52. doi: 10.1172/JCI27125. J Clin Invest. 2006. PMID: 16511604 Free PMC article.
Modulation of LMNA splicing as a strategy to treat prelamin A diseases.
Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett CF, Young SG, Fong LG. Lee JM, et al. Among authors: bennett cf. J Clin Invest. 2016 Apr 1;126(4):1592-602. doi: 10.1172/JCI85908. Epub 2016 Mar 21. J Clin Invest. 2016. PMID: 26999604 Free PMC article.
Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. Fong LG, et al. Among authors: bennett cf. Hum Mol Genet. 2009 Jul 1;18(13):2462-71. doi: 10.1093/hmg/ddp184. Epub 2009 Apr 17. Hum Mol Genet. 2009. PMID: 19376814 Free PMC article.
High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS).
He C, Migawa MT, Chen K, Weston TA, Tanowitz M, Song W, Guagliardo P, Iyer KS, Bennett CF, Fong LG, Seth PP, Young SG, Jiang H. He C, et al. Among authors: bennett cf. Nucleic Acids Res. 2021 Jan 11;49(1):1-14. doi: 10.1093/nar/gkaa1112. Nucleic Acids Res. 2021. PMID: 33275144 Free PMC article.
Antisense oligonucleotide therapy for neurodegenerative disease.
Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW. Smith RA, et al. Among authors: bennett cf. J Clin Invest. 2006 Aug;116(8):2290-6. doi: 10.1172/JCI25424. Epub 2006 Jul 27. J Clin Invest. 2006. PMID: 16878173 Free PMC article.
Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue.
Wancewicz EV, Maier MA, Siwkowski AM, Albertshofer K, Winger TM, Berdeja A, Gaus H, Vickers TA, Bennett CF, Monia BP, Griffey RH, Nulf CJ, Hu J, Corey DR, Swayze EE, Kinberger GA. Wancewicz EV, et al. Among authors: bennett cf. J Med Chem. 2010 May 27;53(10):3919-26. doi: 10.1021/jm901489k. J Med Chem. 2010. PMID: 20420385 Free PMC article.
Fully modified 2' MOE oligonucleotides redirect polyadenylation.
Vickers TA, Wyatt JR, Burckin T, Bennett CF, Freier SM. Vickers TA, et al. Among authors: bennett cf. Nucleic Acids Res. 2001 Mar 15;29(6):1293-9. doi: 10.1093/nar/29.6.1293. Nucleic Acids Res. 2001. PMID: 11238995 Free PMC article.
284 results