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Tamoxifen-stimulated growth of breast cancer due to p21 loss.
Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, Konishi Y, Blair BG, Brenner K, Garrett-Mayer E, Carraway H, Bachman KE, Park BH. Abukhdeir AM, et al. Among authors: konishi h, konishi y. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):288-93. doi: 10.1073/pnas.0710887105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162533 Free PMC article.
PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells.
Higgins MJ, Beaver JA, Wong HY, Gustin JP, Lauring JD, Garay JP, Konishi H, Mohseni M, Wang GM, Cidado J, Jelovac D, Cosgrove DP, Tamaki A, Abukhdeir AM, Park BH. Higgins MJ, et al. Among authors: konishi h. Cancer Biol Ther. 2011 Feb 1;11(3):358-67. doi: 10.4161/cbt.11.3.14227. Epub 2011 Feb 1. Cancer Biol Ther. 2011. PMID: 21124076 Free PMC article.
The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation.
Garay JP, Karakas B, Abukhdeir AM, Cosgrove DP, Gustin JP, Higgins MJ, Konishi H, Konishi Y, Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P, Park BH. Garay JP, et al. Among authors: konishi h, konishi y. Breast Cancer Res. 2012 Feb 9;14(1):R27. doi: 10.1186/bcr3112. Breast Cancer Res. 2012. PMID: 22321971 Free PMC article.
Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.
Wang GM, Wong HY, Konishi H, Blair BG, Abukhdeir AM, Gustin JP, Rosen DM, Denmeade SR, Rasheed Z, Matsui W, Garay JP, Mohseni M, Higgins MJ, Cidado J, Jelovac D, Croessmann S, Cochran RL, Karnan S, Konishi Y, Ota A, Hosokawa Y, Argani P, Lauring J, Park BH. Wang GM, et al. Among authors: konishi h, konishi y. Cancer Res. 2013 Jun 1;73(11):3248-61. doi: 10.1158/0008-5472.CAN-12-1578. Epub 2013 Apr 11. Cancer Res. 2013. PMID: 23580570 Free PMC article.
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.
Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins MJ, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults PJ, Park BH. Lauring J, et al. Among authors: konishi h. Oncogene. 2010 Apr 22;29(16):2337-45. doi: 10.1038/onc.2009.516. Epub 2010 Jan 25. Oncogene. 2010. PMID: 20101210 Free PMC article.
The PIK3CA gene is mutated with high frequency in human breast cancers.
Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH. Bachman KE, et al. Among authors: konishi h. Cancer Biol Ther. 2004 Aug;3(8):772-5. doi: 10.4161/cbt.3.8.994. Epub 2004 Aug 26. Cancer Biol Ther. 2004. PMID: 15254419
1,601 results