Pearce RE - Search Results

1

Biotransformation of fluticasone: in vitro characterization.

Pearce RE, Leeder JS, Kearns GL. Pearce RE, et al. Drug Metab Dispos. 2006 Jun;34(6):1035-40. doi: 10.1124/dmd.105.009043. Epub 2006 Mar 24. Drug Metab Dispos. 2006. PMID: 16565171

2

Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine.

Marcucci KA, Pearce RE, Crespi C, Steimel DT, Leeder JS, Gaedigk A. Marcucci KA, et al. Among authors: pearce re. Drug Metab Dispos. 2002 May;30(5):595-601. doi: 10.1124/dmd.30.5.595. Drug Metab Dispos. 2002. PMID: 11950793

3

Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.

Pearce RE, Vakkalagadda GR, Leeder JS. Pearce RE, et al. Drug Metab Dispos. 2002 Nov;30(11):1170-9. doi: 10.1124/dmd.30.11.1170. Drug Metab Dispos. 2002. PMID: 12386121

4

Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene.

Pearce RE, Uetrecht JP, Leeder JS. Pearce RE, et al. Drug Metab Dispos. 2005 Dec;33(12):1819-26. doi: 10.1124/dmd.105.004861. Epub 2005 Aug 31. Drug Metab Dispos. 2005. PMID: 16135660

5

CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile.

Kang P, Liao M, Wester MR, Leeder JS, Pearce RE, Correia MA. Kang P, et al. Among authors: pearce re. Drug Metab Dispos. 2008 Mar;36(3):490-9. doi: 10.1124/dmd.107.016501. Epub 2007 Dec 20. Drug Metab Dispos. 2008. PMID: 18096676 Free PMC article.

6

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.

Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS. Pearce RE, et al. Drug Metab Dispos. 2008 Aug;36(8):1637-49. doi: 10.1124/dmd.107.019562. Epub 2008 May 7. Drug Metab Dispos. 2008. PMID: 18463198 Free PMC article.

7

The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst.

Pearce RE, Cohen-Wolkowiez M, Sampson MR, Kearns GL. Pearce RE, et al. Drug Metab Dispos. 2013 Sep;41(9):1686-94. doi: 10.1124/dmd.113.052548. Epub 2013 Jun 27. Drug Metab Dispos. 2013. PMID: 23813797 Free PMC article.

8

Variability in Expression of CYP3A5 in Human Fetal Liver.

Vyhlidal CA, Pearce RE, Gaedigk R, Calamia JC, Shuster DL, Thummel KE, Leeder JS. Vyhlidal CA, et al. Among authors: pearce re. Drug Metab Dispos. 2015 Aug;43(8):1286-93. doi: 10.1124/dmd.115.064998. Epub 2015 May 15. Drug Metab Dispos. 2015. PMID: 25979262 Free PMC article.

9

In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.

Goldman JL, Leeder JS, Van Haandel L, Pearce RE. Goldman JL, et al. Among authors: pearce re. Drug Metab Dispos. 2015 Sep;43(9):1372-80. doi: 10.1124/dmd.115.065193. Epub 2015 Jul 2. Drug Metab Dispos. 2015. PMID: 26138612 Free PMC article.

10

Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.

Pearce RE, Gaedigk R, Twist GP, Dai H, Riffel AK, Leeder JS, Gaedigk A. Pearce RE, et al. Drug Metab Dispos. 2016 Jul;44(7):948-58. doi: 10.1124/dmd.115.067546. Epub 2015 Nov 25. Drug Metab Dispos. 2016. PMID: 26608082 Free PMC article.

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