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Synthesis and antihypertensive activity of pyran oxygen and amide nitrogen replacement analogues of the potassium channel activator cromakalim.

Ashwood VA, Cassidy F, Evans JM, Gagliardi S, Stemp G. Ashwood VA, et al. J Med Chem. 1991 Nov;34(11):3261-7. doi: 10.1021/jm00115a015. J Med Chem. 1991. PMID: 1659637

Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans.

Ashwood VA, Cassidy F, Coldwell MC, Evans JM, Hamilton TC, Howlett DR, Smith DM, Stemp G. Ashwood VA, et al. J Med Chem. 1990 Sep;33(9):2667-72. doi: 10.1021/jm00171a051. J Med Chem. 1990. PMID: 2391705

Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans.

Ashwood VA, Buckingham RE, Cassidy F, Evans JM, Faruk EA, Hamilton TC, Nash DJ, Stemp G, Willcocks K. Ashwood VA, et al. J Med Chem. 1986 Nov;29(11):2194-201. doi: 10.1021/jm00161a011. J Med Chem. 1986. PMID: 3783581

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.

Ashwood VA, Field MJ, Horwell DC, Julien-Larose C, Lewthwaite RA, McCleary S, Pritchard MC, Raphy J, Singh L. Ashwood VA, et al. J Med Chem. 2001 Jul 5;44(14):2276-85. doi: 10.1021/jm010825z. J Med Chem. 2001. PMID: 11428921

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

Ashwood V, Brownhill V, Higginbottom M, Horwell DC, Hughes J, Lewthwaite RA, McKnight AT, Pinnock RD, Pritchard MC, Suman-Chauhan N, Webb C, Williams SC. Ashwood V, et al. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94. doi: 10.1016/s0960-894x(98)00462-4. Bioorg Med Chem Lett. 1998. PMID: 9873586

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