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Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas.
Pfister S, Remke M, Toedt G, Werft W, Benner A, Mendrzyk F, Wittmann A, Devens F, von Hoff K, Rutkowski S, Kulozik A, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A. Pfister S, et al. Among authors: korshunov a. Genes Chromosomes Cancer. 2007 Sep;46(9):839-51. doi: 10.1002/gcc.20471. Genes Chromosomes Cancer. 2007. PMID: 17592618
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.
Pfister S, Janzarik WG, Remke M, Ernst A, Werft W, Becker N, Toedt G, Wittmann A, Kratz C, Olbrich H, Ahmadi R, Thieme B, Joos S, Radlwimmer B, Kulozik A, Pietsch T, Herold-Mende C, Gnekow A, Reifenberger G, Korshunov A, Scheurlen W, Omran H, Lichter P. Pfister S, et al. Among authors: korshunov a. J Clin Invest. 2008 May;118(5):1739-49. doi: 10.1172/JCI33656. J Clin Invest. 2008. PMID: 18398503 Free PMC article.
521 results