Smith K - Search Results

1

New potential antimalarial agents: therapeutic-index evaluation of pyrroloquinazolinediamine and its prodrugs in a rat model of severe malaria.

Xie LH, Li Q, Lin AJ, Smith K, Zhang J, Skillman DS. Xie LH, et al. Among authors: smith k. Antimicrob Agents Chemother. 2006 May;50(5):1649-55. doi: 10.1128/AAC.50.5.1649-1655.2006. Antimicrob Agents Chemother. 2006. PMID: 16641431 Free PMC article.

2

Pharmacokinetics, safety, and hydrolysis of oral pyrroloquinazolinediamines administered in single and multiple doses in rats.

Li Q, Kozar MP, Shearer TW, Xie LH, Lin AJ, Smith KS, Si Y, Anova L, Zhang J, Milhous WK, Skillman DR. Li Q, et al. Among authors: smith ks. Antimicrob Agents Chemother. 2007 Aug;51(8):2898-904. doi: 10.1128/AAC.00932-06. Epub 2007 Jun 11. Antimicrob Agents Chemother. 2007. PMID: 17562804 Free PMC article.

3

Malaria causal prophylactic activity of imidazolidinedione derivatives.

Guan J, Wang X, Smith K, Ager A, Gettayacamin M, Kyle DE, Milhous WK, Kozar MP, Magill AJ, Lin AJ. Guan J, et al. Among authors: smith k. J Med Chem. 2007 Nov 29;50(24):6226-31. doi: 10.1021/jm7009815. Epub 2007 Oct 30. J Med Chem. 2007. PMID: 17967003

4

Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles.

Li Q, Si Y, Smith KS, Zeng Q, Weina PJ. Li Q, et al. Birth Defects Res B Dev Reprod Toxicol. 2008 Aug;83(4):435-45. doi: 10.1002/bdrb.20164. Birth Defects Res B Dev Reprod Toxicol. 2008. PMID: 18636509

5

Mefloquine induces dose-related neurological effects in a rat model.

Dow G, Bauman R, Caridha D, Cabezas M, Du F, Gomez-Lobo R, Park M, Smith K, Cannard K. Dow G, et al. Among authors: smith k. Antimicrob Agents Chemother. 2006 Mar;50(3):1045-53. doi: 10.1128/AAC.50.3.1045-1053.2006. Antimicrob Agents Chemother. 2006. PMID: 16495267 Free PMC article.

6

Utility of alkylaminoquinolinyl methanols as new antimalarial drugs.

Dow GS, Heady TN, Bhattacharjee AK, Caridha D, Gerena L, Gettayacamin M, Lanteri CA, Obaldia N 3rd, Roncal N, Shearer T, Smith PL, Tungtaeng A, Wolf L, Cabezas M, Yourick D, Smith KS. Dow GS, et al. Among authors: smith pl, smith ks. Antimicrob Agents Chemother. 2006 Dec;50(12):4132-43. doi: 10.1128/AAC.00631-06. Epub 2006 Sep 11. Antimicrob Agents Chemother. 2006. PMID: 16966402 Free PMC article.

7

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate--JPC2056--in cynomolgus monkeys using an in vivo in vitro model.

Edstein MD, Kotecka BM, Ager AL, Smith KS, DiTusa CA, Diaz DS, Kyle DE, Schiehser GA, Jacobus DP, Rieckmann KH, O'Neil MT. Edstein MD, et al. J Antimicrob Chemother. 2007 Oct;60(4):811-8. doi: 10.1093/jac/dkm280. Epub 2007 Jul 23. J Antimicrob Chemother. 2007. PMID: 17646199

8

The role of in vitro ADME assays in antimalarial drug discovery and development.

Shearer TW, Smith KS, Diaz D, Asher C, Ramirez J. Shearer TW, et al. Comb Chem High Throughput Screen. 2005 Feb;8(1):89-98. doi: 10.2174/1386207053328129. Comb Chem High Throughput Screen. 2005. PMID: 15720200 Review.

9

Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.

Diaz DS, Kozar MP, Smith KS, Asher CO, Sousa JC, Schiehser GA, Jacobus DP, Milhous WK, Skillman DR, Shearer TW. Diaz DS, et al. Among authors: smith ks. Drug Metab Dispos. 2008 Feb;36(2):380-5. doi: 10.1124/dmd.106.013920. Epub 2007 Nov 15. Drug Metab Dispos. 2008. PMID: 18006651

10

In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum.

Gutteridge CE, Nichols DA, Curtis SM, Thota DS, Vo JV, Gerena L, Montip G, Asher CO, Diaz DS, Ditusa CA, Smith KS, Bhattacharjee AK. Gutteridge CE, et al. Among authors: smith ks. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5682-6. doi: 10.1016/j.bmcl.2006.08.009. Epub 2006 Aug 14. Bioorg Med Chem Lett. 2006. PMID: 16908136

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