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Bcl-2 changes conformation to inhibit Bax oligomerization.
Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B, Andrews DW. Dlugosz PJ, et al. Among authors: zhu w. EMBO J. 2006 Jun 7;25(11):2287-96. doi: 10.1038/sj.emboj.7601126. Epub 2006 Apr 27. EMBO J. 2006. PMID: 16642033 Free PMC article.
A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW. Niu X, et al. Among authors: zhu w. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5. doi: 10.1016/j.chembiol.2017.03.011. Epub 2017 Apr 6. Cell Chem Biol. 2017. PMID: 28392146 Free PMC article.
Bax forms an oligomer via separate, yet interdependent, surfaces.
Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, Zhang XC, Andrews DW, Lin J. Zhang Z, et al. Among authors: zhu w. J Biol Chem. 2010 Jun 4;285(23):17614-27. doi: 10.1074/jbc.M110.113456. Epub 2010 Apr 9. J Biol Chem. 2010. PMID: 20382739 Free PMC article.
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