Barbuch RJ - Search Results

1

Selective metabolism of vincristine in vitro by CYP3A5.

Dennison JB, Kulanthaivel P, Barbuch RJ, Renbarger JL, Ehlhardt WJ, Hall SD. Dennison JB, et al. Among authors: barbuch rj. Drug Metab Dispos. 2006 Aug;34(8):1317-27. doi: 10.1124/dmd.106.009902. Epub 2006 May 5. Drug Metab Dispos. 2006. PMID: 16679390

2

Selective reduction of N-oxides to amines: application to drug metabolism.

Kulanthaivel P, Barbuch RJ, Davidson RS, Yi P, Rener GA, Mattiuz EL, Hadden CE, Goodwin LA, Ehlhardt WJ. Kulanthaivel P, et al. Among authors: barbuch rj. Drug Metab Dispos. 2004 Sep;32(9):966-72. Drug Metab Dispos. 2004. PMID: 15319338

3

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.

Dennison JB, Mohutsky MA, Barbuch RJ, Wrighton SA, Hall SD. Dennison JB, et al. Among authors: barbuch rj. J Pharmacol Exp Ther. 2008 Oct;327(1):248-57. doi: 10.1124/jpet.108.139998. Epub 2008 Jul 23. J Pharmacol Exp Ther. 2008. PMID: 18650247

4

The relative contributions of CYP3A4 and CYP3A5 to the metabolism of vinorelbine.

Topletz AR, Dennison JB, Barbuch RJ, Hadden CE, Hall SD, Renbarger JL. Topletz AR, et al. Among authors: barbuch rj. Drug Metab Dispos. 2013 Sep;41(9):1651-61. doi: 10.1124/dmd.113.051094. Epub 2013 Jun 18. Drug Metab Dispos. 2013. PMID: 23780963 Free PMC article.

5

In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.

Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P. Barbuch RJ, et al. Drug Metab Dispos. 2006 Feb;34(2):213-24. doi: 10.1124/dmd.105.007401. Epub 2005 Oct 28. Drug Metab Dispos. 2006. PMID: 16258078

6

Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans.

Yi P, Hadden C, Kulanthaivel P, Calvert N, Annes W, Brown T, Barbuch RJ, Chaudhary A, Ayan-Oshodi MA, Ring BJ. Yi P, et al. Among authors: barbuch rj. Drug Metab Dispos. 2010 Apr;38(4):554-65. doi: 10.1124/dmd.109.030841. Epub 2010 Jan 14. Drug Metab Dispos. 2010. PMID: 20075192

7

Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.

Zamek-Gliszczynski MJ, Abraham TL, Alberts JJ, Kulanthaivel P, Jackson KA, Chow KH, McCann DJ, Hu H, Anderson S, Furr NA, Barbuch RJ, Cassidy KC. Zamek-Gliszczynski MJ, et al. Among authors: barbuch rj. Drug Metab Dispos. 2013 Apr;41(4):714-26. doi: 10.1124/dmd.112.048488. Epub 2013 Jan 10. Drug Metab Dispos. 2013. PMID: 23305709 Clinical Trial.

8

Metabolism of LY654322, a growth hormone secretagogue, to an unusual diimidazopyridine metabolite.

Borel AG, Jones TM, Barbuch RJ, Jackson DA, Kulanthaivel P, Mattiuz E, Klimkowski VJ, Wheeler WJ, Rener GA. Borel AG, et al. Among authors: barbuch rj. Drug Metab Dispos. 2011 May;39(5):740-9. doi: 10.1124/dmd.110.037598. Epub 2011 Feb 23. Drug Metab Dispos. 2011. PMID: 21346003

9

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

Mattiuz EL, Ponsler GD, Barbuch RJ, Wood PG, Mullen JH, Shugert RL, Li Q, Wheeler WJ, Kuo F, Conrad PC, Sauer JM. Mattiuz EL, et al. Among authors: barbuch rj. Drug Metab Dispos. 2003 Jan;31(1):88-97. doi: 10.1124/dmd.31.1.88. Drug Metab Dispos. 2003. PMID: 12485957

10

Disposition of [14C]ruboxistaurin in humans.

Burkey JL, Campanale KM, Barbuch R, O'Bannon D, Rash J, Benson C, Small D. Burkey JL, et al. Drug Metab Dispos. 2006 Nov;34(11):1909-17. doi: 10.1124/dmd.106.009894. Epub 2006 Aug 8. Drug Metab Dispos. 2006. PMID: 16896067 Clinical Trial.

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