Chen J - Search Results

1

Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.

Stover EH, Chen J, Folens C, Lee BH, Mentens N, Marynen P, Williams IR, Gilliland DG, Cools J. Stover EH, et al. Among authors: chen j. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8078-83. doi: 10.1073/pnas.0601192103. Epub 2006 May 11. Proc Natl Acad Sci U S A. 2006. PMID: 16690743 Free PMC article.

2

Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation.

Chen J, Williams IR, Kutok JL, Duclos N, Anastasiadou E, Masters SC, Fu H, Gilliland DG. Chen J, et al. Blood. 2004 Jul 15;104(2):535-42. doi: 10.1182/blood-2004-01-0169. Epub 2004 Mar 30. Blood. 2004. PMID: 15054045 Free article.

3

Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin.

Chen J, Wall NR, Kocher K, Duclos N, Fabbro D, Neuberg D, Griffin JD, Shi Y, Gilliland DG. Chen J, et al. J Clin Invest. 2004 Jun;113(12):1784-91. doi: 10.1172/JCI20673. J Clin Invest. 2004. PMID: 15199413 Free PMC article.

4

PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.

Chen J, Deangelo DJ, Kutok JL, Williams IR, Lee BH, Wadleigh M, Duclos N, Cohen S, Adelsperger J, Okabe R, Coburn A, Galinsky I, Huntly B, Cohen PS, Meyer T, Fabbro D, Roesel J, Banerji L, Griffin JD, Xiao S, Fletcher JA, Stone RM, Gilliland DG. Chen J, et al. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14479-84. doi: 10.1073/pnas.0404438101. Epub 2004 Sep 24. Proc Natl Acad Sci U S A. 2004. PMID: 15448205 Free PMC article.

5

Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation.

Chen J, Williams IR, Lee BH, Duclos N, Huntly BJ, Donoghue DJ, Gilliland DG. Chen J, et al. Blood. 2005 Jul 1;106(1):328-37. doi: 10.1182/blood-2004-09-3686. Epub 2005 Mar 22. Blood. 2005. PMID: 15784730 Free PMC article.

6

The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo.

Stover EH, Chen J, Lee BH, Cools J, McDowell E, Adelsperger J, Cullen D, Coburn A, Moore SA, Okabe R, Fabbro D, Manley PW, Griffin JD, Gilliland DG. Stover EH, et al. Among authors: chen j. Blood. 2005 Nov 1;106(9):3206-13. doi: 10.1182/blood-2005-05-1932. Epub 2005 Jul 19. Blood. 2005. PMID: 16030188 Free PMC article.

7

FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies.

Chen J, Lee BH, Williams IR, Kutok JL, Mitsiades CS, Duclos N, Cohen S, Adelsperger J, Okabe R, Coburn A, Moore S, Huntly BJ, Fabbro D, Anderson KC, Griffin JD, Gilliland DG. Chen J, et al. Oncogene. 2005 Dec 15;24(56):8259-67. doi: 10.1038/sj.onc.1208989. Oncogene. 2005. PMID: 16091734

8

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. Kang S, et al. Among authors: chen j. Cancer Cell. 2007 Sep;12(3):201-14. doi: 10.1016/j.ccr.2007.08.003. Cancer Cell. 2007. PMID: 17785202 Free PMC article.

9

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.

Tam WF, Gu TL, Chen J, Lee BH, Bullinger L, Fröhling S, Wang A, Monti S, Golub TR, Gilliland DG. Tam WF, et al. Among authors: chen j. Blood. 2008 Sep 1;112(5):1981-92. doi: 10.1182/blood-2007-07-103010. Epub 2008 Jun 17. Blood. 2008. PMID: 18559972 Free PMC article.

10

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.

Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J. Kang S, et al. Among authors: chen j. Mol Cell Biol. 2009 Apr;29(8):2105-17. doi: 10.1128/MCB.00998-08. Epub 2009 Feb 17. Mol Cell Biol. 2009. PMID: 19223461 Free PMC article.

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