Heegaard NH - Search Results

1

Variants of beta-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature.

Mimmi MC, Jørgensen TJ, Pettirossi F, Corazza A, Viglino P, Esposito G, De Lorenzi E, Giorgetti S, Pries M, Corlin DB, Nissen MH, Heegaard NH. Mimmi MC, et al. Among authors: heegaard nh. FEBS J. 2006 Jun;273(11):2461-74. doi: 10.1111/j.1742-4658.2006.05254.x. FEBS J. 2006. PMID: 16704420 Free article.

2

Interconverting conformations of variants of the human amyloidogenic protein beta2-microglobulin quantitatively characterized by dynamic capillary electrophoresis and computer simulation.

Heegaard NH, Jørgensen TJ, Cheng L, Schou C, Nissen MH, Trapp O. Heegaard NH, et al. Anal Chem. 2006 Jun 1;78(11):3667-73. doi: 10.1021/ac060194m. Anal Chem. 2006. PMID: 16737222

3

A beta2-microglobulin cleavage variant fibrillates at near-physiological pH.

Corlin DB, Johnsen CK, Nissen MH, Heegaard NH. Corlin DB, et al. Among authors: heegaard nh. Biochem Biophys Res Commun. 2009 Apr 3;381(2):187-91. doi: 10.1016/j.bbrc.2009.02.041. Epub 2009 Feb 14. Biochem Biophys Res Commun. 2009. PMID: 19232323

4

β(2)-microglobulin amyloidosis.

Corlin DB, Heegaard NH. Corlin DB, et al. Among authors: heegaard nh. Subcell Biochem. 2012;65:517-40. doi: 10.1007/978-94-007-5416-4_19. Subcell Biochem. 2012. PMID: 23225015 Review.

5

Cleaved beta 2-microglobulin partially attains a conformation that has amyloidogenic features.

Heegaard NH, Roepstorff P, Melberg SG, Nissen MH. Heegaard NH, et al. J Biol Chem. 2002 Mar 29;277(13):11184-9. doi: 10.1074/jbc.M108837200. Epub 2002 Jan 18. J Biol Chem. 2002. PMID: 11801591 Free article.

6

Structural and conformational variants of human beta2-microglobulin characterized by capillary electrophoresis and complementary separation methods.

Heegaard NH, Rovatti L, Nissen MH, Hamdan M. Heegaard NH, et al. J Chromatogr A. 2003 Jul 4;1004(1-2):51-9. doi: 10.1016/s0021-9673(03)00719-2. J Chromatogr A. 2003. PMID: 12929961

7

Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin.

Heegaard NH, Jørgensen TJ, Rozlosnik N, Corlin DB, Pedersen JS, Tempesta AG, Roepstorff P, Bauer R, Nissen MH. Heegaard NH, et al. Biochemistry. 2005 Mar 22;44(11):4397-407. doi: 10.1021/bi047594t. Biochemistry. 2005. PMID: 15766269

8

Quantification of cleaved beta2-microglobulin in serum from patients undergoing chronic hemodialysis.

Corlin DB, Sen JW, Ladefoged S, Lund GB, Nissen MH, Heegaard NH. Corlin DB, et al. Among authors: heegaard nh. Clin Chem. 2005 Jul;51(7):1177-84. doi: 10.1373/clinchem.2005.049544. Epub 2005 May 12. Clin Chem. 2005. PMID: 15890888

9

Interactions of charged ligands with beta(2)-microglobulin conformers in affinity capillary electrophoresis.

Heegaard NH, De Lorenzi E. Heegaard NH, et al. Biochim Biophys Acta. 2005 Nov 10;1753(1):131-40. doi: 10.1016/j.bbapap.2005.07.005. Epub 2005 Aug 19. Biochim Biophys Acta. 2005. PMID: 16112627 Review.

10

Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.

Giorgetti S, Stoppini M, Tennent GA, Relini A, Marchese L, Raimondi S, Monti M, Marini S, Østergaard O, Heegaard NH, Pucci P, Esposito G, Merlini G, Bellotti V. Giorgetti S, et al. Among authors: heegaard nh. Protein Sci. 2007 Feb;16(2):343-9. doi: 10.1110/ps.062563507. Protein Sci. 2007. PMID: 17242436 Free PMC article.

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