Witola WH - Search Results

1

Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus.

Witola WH, Pessi G, El Bissati K, Reynolds JM, Mamoun CB. Witola WH, et al. J Biol Chem. 2006 Jul 28;281(30):21305-21311. doi: 10.1074/jbc.M603260200. Epub 2006 May 16. J Biol Chem. 2006. PMID: 16704982 Free article.

2

Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects.

Witola WH, El Bissati K, Pessi G, Xie C, Roepe PD, Mamoun CB. Witola WH, et al. J Biol Chem. 2008 Oct 10;283(41):27636-27643. doi: 10.1074/jbc.M804360200. Epub 2008 Aug 11. J Biol Chem. 2008. PMID: 18694927 Free PMC article.

3

The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.

El Bissati K, Zufferey R, Witola WH, Carter NS, Ullman B, Ben Mamoun C. El Bissati K, et al. Among authors: witola wh. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9286-91. doi: 10.1073/pnas.0602590103. Epub 2006 Jun 2. Proc Natl Acad Sci U S A. 2006. PMID: 16751273 Free PMC article.

4

Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum.

Reynolds JM, Takebe S, Choi JY, El Bissati K, Witola WH, Bobenchik AM, Hoch JC, Voelker DR, Mamoun CB. Reynolds JM, et al. Among authors: witola wh. J Biol Chem. 2008 Mar 21;283(12):7894-900. doi: 10.1074/jbc.M709869200. Epub 2008 Jan 4. J Biol Chem. 2008. PMID: 18178564 Free article.

5

A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum.

Le Roch KG, Johnson JR, Ahiboh H, Chung DW, Prudhomme J, Plouffe D, Henson K, Zhou Y, Witola W, Yates JR, Mamoun CB, Winzeler EA, Vial H. Le Roch KG, et al. BMC Genomics. 2008 Oct 30;9:513. doi: 10.1186/1471-2164-9-513. BMC Genomics. 2008. PMID: 18973684 Free PMC article.

6

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus.

Jirage D, Chen Y, Caridha D, O'Neil MT, Eyase F, Witola WH, Mamoun CB, Waters NC. Jirage D, et al. Among authors: witola wh. Mol Biochem Parasitol. 2010 Jul;172(1):9-18. doi: 10.1016/j.molbiopara.2010.03.009. Epub 2010 Mar 21. Mol Biochem Parasitol. 2010. PMID: 20332005

7

Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase.

Witola WH, Ben Mamoun C. Witola WH, et al. Eukaryot Cell. 2007 Sep;6(9):1618-24. doi: 10.1128/EC.00229-07. Epub 2007 Jul 20. Eukaryot Cell. 2007. PMID: 17644653 Free PMC article.

8

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.

Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Pieroni M, Stec J, Muench SP, Rice DW, Kozikowski AP, McLeod R. Fomovska A, et al. Among authors: witola wh. Antimicrob Agents Chemother. 2012 May;56(5):2666-82. doi: 10.1128/AAC.06450-11. Epub 2012 Feb 21. Antimicrob Agents Chemother. 2012. PMID: 22354304 Free PMC article.

9

Purification of components of the translation elongation factor complex of Plasmodium falciparum by tandem affinity purification.

Takebe S, Witola WH, Schimanski B, Günzl A, Ben Mamoun C. Takebe S, et al. Among authors: witola wh. Eukaryot Cell. 2007 Apr;6(4):584-91. doi: 10.1128/EC.00376-06. Epub 2007 Feb 16. Eukaryot Cell. 2007. PMID: 17307963 Free PMC article.

10

Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections.

Lai BS, Witola WH, El Bissati K, Zhou Y, Mui E, Fomovska A, McLeod R. Lai BS, et al. Among authors: witola wh. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14182-7. doi: 10.1073/pnas.1208775109. Epub 2012 Aug 13. Proc Natl Acad Sci U S A. 2012. PMID: 22891343 Free PMC article.

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