Motyl M - Search Results

1

Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB. Wang J, et al. Among authors: motyl m. Nature. 2006 May 18;441(7091):358-61. doi: 10.1038/nature04784. Nature. 2006. PMID: 16710421

2

Comparative in vitro activities of ertapenem against aerobic and facultative bacterial pathogens from patients with complicated skin and skin structure infections.

Pelak BA, Bartizal K, Woods GL, Gesser RM, Motyl M. Pelak BA, et al. Among authors: motyl m. Diagn Microbiol Infect Dis. 2002 Jun;43(2):129-33. doi: 10.1016/s0732-8893(02)00387-5. Diagn Microbiol Infect Dis. 2002. PMID: 12088620

3

Comparative in-vitro activities of ertapenem against aerobic bacterial pathogens isolated from patients with complicated intra-abdominal infections.

Pelak BA, Woods GL, Teppler H, Friedland I, Bartizal K, Motyl M. Pelak BA, et al. Among authors: motyl m. J Chemother. 2002 Jun;14(3):227-33. doi: 10.1179/joc.2002.14.3.227. J Chemother. 2002. PMID: 12120874

4

Comparative in vitro activity of ertapenem against bacterial pathogens isolated from patients with lower respiratory tract infections.

Hicks PS, Pelak B, Woods GL, Bartizal KF, Motyl M. Hicks PS, et al. Among authors: motyl m. Clin Microbiol Infect. 2002 Nov;8(11):753-7. doi: 10.1046/j.1469-0691.2002.00461.x. Clin Microbiol Infect. 2002. PMID: 12445016 Free article.

5

What are we looking for in new antibacterials and how do we design it?

Barrett JF, Motyl M. Barrett JF, et al. Among authors: motyl m. Expert Opin Investig Drugs. 2006 Feb;15(2):85-8. doi: 10.1517/13543784.15.2.85. Expert Opin Investig Drugs. 2006. PMID: 16433588

6

Coniothyrione, a chlorocyclopentandienylbenzopyrone as a bacterial protein synthesis inhibitor discovered by antisense technology.

Ondeyka JG, Zink D, Basilio A, Vicente F, Bills G, Diez MT, Motyl M, Dezeny G, Byrne K, Singh SB. Ondeyka JG, et al. Among authors: motyl m. J Nat Prod. 2007 Apr;70(4):668-70. doi: 10.1021/np060557d. Epub 2007 Mar 9. J Nat Prod. 2007. PMID: 17346074

7

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB. Wang J, et al. Among authors: motyl m. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6. doi: 10.1073/pnas.0700746104. Epub 2007 Apr 24. Proc Natl Acad Sci U S A. 2007. PMID: 17456595 Free PMC article.

8

Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.

Singh SB, Occi J, Jayasuriya H, Herath K, Motyl M, Dorso K, Gill C, Hickey E, Overbye KM, Barrett JF, Masurekar P. Singh SB, et al. Among authors: motyl m. J Antibiot (Tokyo). 2007 Sep;60(9):565-71. doi: 10.1038/ja.2007.71. J Antibiot (Tokyo). 2007. PMID: 17917239

9

Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy.

Zhang C, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Huber J, Dorso K, Motyl M, Byrne K, Singh SB. Zhang C, et al. Among authors: motyl m. Bioorg Med Chem. 2009 Mar 15;17(6):2162-6. doi: 10.1016/j.bmc.2008.04.018. Epub 2008 Apr 12. Bioorg Med Chem. 2009. PMID: 18442914

10

Isolation, structure, and antibacterial activity of phaeosphenone from a Phaeosphaeria sp. discovered by antisense strategy.

Zhang C, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Bills G, Huber J, Dorso K, Motyl M, Byrne K, Singh SB. Zhang C, et al. Among authors: motyl m. J Nat Prod. 2008 Jul;71(7):1304-7. doi: 10.1021/np8001833. Epub 2008 Jun 21. J Nat Prod. 2008. PMID: 18570471

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