Massa S - Search Results

1

3-D QSAR studies on histone deacetylase inhibitors. A GOLPE/GRID approach on different series of compounds.

Ragno R, Simeoni S, Valente S, Massa S, Mai A. Ragno R, et al. Among authors: massa s. J Chem Inf Model. 2006 May-Jun;46(3):1420-30. doi: 10.1021/ci050556b. J Chem Inf Model. 2006. PMID: 16711762

2

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures.

Mai A, Massa S, Ragno R, Cerbara I, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: massa s. J Med Chem. 2003 Feb 13;46(4):512-24. doi: 10.1021/jm021070e. J Med Chem. 2003. PMID: 12570373

Recently we reported a novel series of hydroxamates, called 3-(4-aroyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides (APHAs), acting as HDAC inhibitors (Massa, S.; et al. J. Med. Chem. 2001, 44, 2069-2072). Among them, 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-prop …

Recently we reported a novel series of hydroxamates, called 3-(4-aroyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides (APHAs), acting as HDAC inhib …

3

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.

Mai A, Massa S, Cerbara I, Valente S, Ragno R, Bottoni P, Scatena R, Loidl P, Brosch G. Mai A, et al. Among authors: massa s. J Med Chem. 2004 Feb 26;47(5):1098-109. doi: 10.1021/jm030990+. J Med Chem. 2004. PMID: 14971890

4

3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.

Ragno R, Mai A, Massa S, Cerbara I, Valente S, Bottoni P, Scatena R, Jesacher F, Loidl P, Brosch G. Ragno R, et al. Among authors: massa s. J Med Chem. 2004 Mar 11;47(6):1351-9. doi: 10.1021/jm031036f. J Med Chem. 2004. PMID: 14998325

5

Histone deacetylation in epigenetics: an attractive target for anticancer therapy.

Mai A, Massa S, Rotili D, Cerbara I, Valente S, Pezzi R, Simeoni S, Ragno R. Mai A, et al. Among authors: massa s. Med Res Rev. 2005 May;25(3):261-309. doi: 10.1002/med.20024. Med Res Rev. 2005. PMID: 15717297 Review.

6

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

Mai A, Massa S, Pezzi R, Simeoni S, Rotili D, Nebbioso A, Scognamiglio A, Altucci L, Loidl P, Brosch G. Mai A, et al. Among authors: massa s. J Med Chem. 2005 May 5;48(9):3344-53. doi: 10.1021/jm049002a. J Med Chem. 2005. PMID: 15857140

7

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. Mai A, et al. Among authors: massa s. J Med Chem. 2005 Dec 1;48(24):7789-95. doi: 10.1021/jm050100l. J Med Chem. 2005. PMID: 16302818

8

Aroyl-pyrrolyl hydroxyamides: influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition.

Mai A, Massa S, Valente S, Simeoni S, Ragno R, Bottoni P, Scatena R, Brosch G. Mai A, et al. Among authors: massa s. ChemMedChem. 2006 Feb;1(2):225-37. doi: 10.1002/cmdc.200500015. ChemMedChem. 2006. PMID: 16892355

9

Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.

Mai A, Massa S, Rotili D, Simeoni S, Ragno R, Botta G, Nebbioso A, Miceli M, Altucci L, Brosch G. Mai A, et al. Among authors: massa s. J Med Chem. 2006 Oct 5;49(20):6046-56. doi: 10.1021/jm0605536. J Med Chem. 2006. PMID: 17004718

10

Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity.

Mai A, Valente S, Rotili D, Massa S, Botta G, Brosch G, Miceli M, Nebbioso A, Altucci L. Mai A, et al. Among authors: massa s. Int J Biochem Cell Biol. 2007;39(7-8):1510-22. doi: 10.1016/j.biocel.2007.03.020. Epub 2007 Apr 4. Int J Biochem Cell Biol. 2007. PMID: 17482499

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