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Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1.
Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Kushman ME, et al. Among authors: townsend aj. Mutat Res. 2007 Nov 1;624(1-2):80-7. doi: 10.1016/j.mrfmmm.2007.04.004. Epub 2007 Apr 19. Mutat Res. 2007. PMID: 17509623 Free PMC article.
Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.
Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ. Kushman ME, et al. Among authors: townsend aj. Carcinogenesis. 2007 Jan;28(1):207-14. doi: 10.1093/carcin/bgl125. Epub 2006 Aug 2. Carcinogenesis. 2007. PMID: 16885195
Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
Kabler SL, Seidel A, Jacob J, Doehmer J, Morrow CS, Townsend AJ. Kabler SL, et al. Among authors: townsend aj. Chem Biol Interact. 2009 May 15;179(2-3):240-6. doi: 10.1016/j.cbi.2009.01.010. Chem Biol Interact. 2009. PMID: 19330882 Free PMC article.
Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1).
Rudd LP, Kabler SL, Morrow CS, Townsend AJ. Rudd LP, et al. Among authors: townsend aj. Chem Biol Interact. 2011 Nov 15;194(2-3):113-9. doi: 10.1016/j.cbi.2011.08.012. Epub 2011 Sep 8. Chem Biol Interact. 2011. PMID: 21925487 Free PMC article.
90 results