Pitis PM - Search Results

1

The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent mu opioid RWJ-413216.

Codd EE, Carson JR, Colburn RW, Dax SL, Desai-Krieger D, Martinez RP, McKown LA, Neilson LA, Pitis PM, Stahle PL, Stone DJ, Streeter AJ, Wu WN, Zhang SP. Codd EE, et al. Among authors: pitis pm. J Pharmacol Exp Ther. 2006 Sep;318(3):1273-9. doi: 10.1124/jpet.106.104208. Epub 2006 Jun 9. J Pharmacol Exp Ther. 2006. PMID: 16766719

2

N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.

Carson JR, Coats SJ, Codd EE, Dax SL, Lee J, Martinez RP, Neilson LA, Pitis PM, Zhang SP. Carson JR, et al. Among authors: pitis pm. Bioorg Med Chem Lett. 2004 May 3;14(9):2109-12. doi: 10.1016/j.bmcl.2004.02.051. Bioorg Med Chem Lett. 2004. PMID: 15080989

3

N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, micro and delta opioid agonists: a micro address.

Carson JR, Coats SJ, Codd EE, Dax SL, Lee J, Martinez RP, McKown LA, Anne Neilson L, Pitis PM, Wu WN, Zhang SP. Carson JR, et al. Among authors: pitis pm. Bioorg Med Chem Lett. 2004 May 3;14(9):2113-6. doi: 10.1016/j.bmcl.2004.02.052. Bioorg Med Chem Lett. 2004. PMID: 15080990

4

Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.

Coats SJ, Schulz MJ, Carson JR, Codd EE, Hlasta DJ, Pitis PM, Stone DJ Jr, Zhang SP, Colburn RW, Dax SL. Coats SJ, et al. Among authors: pitis pm. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5493-8. doi: 10.1016/j.bmcl.2004.09.004. Bioorg Med Chem Lett. 2004. PMID: 15482911

5

Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.

Carson JR, Carmosin RJ, Pitis PM, Vaught JL, Almond HR, Stables JP, Wolf HH, Swinyard EA, White HS. Carson JR, et al. Among authors: pitis pm. J Med Chem. 1997 May 23;40(11):1578-84. doi: 10.1021/jm9606655. J Med Chem. 1997. PMID: 9171868

6

2-Ethynylbenzenealkanamines. A new class of calcium entry blockers.

Carson JR, Almond HR, Brannan MD, Carmosin RJ, Flaim SF, Gill A, Gleason MM, Keely SL, Ludovici DW, Pitis PM, et al. Carson JR, et al. Among authors: pitis pm. J Med Chem. 1988 Mar;31(3):630-6. doi: 10.1021/jm00398a023. J Med Chem. 1988. PMID: 3346879

7

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.

DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. DeWire SM, et al. Among authors: pitis pm. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17. doi: 10.1124/jpet.112.201616. Epub 2013 Jan 8. J Pharmacol Exp Ther. 2013. PMID: 23300227

8

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Chen XT, et al. J Med Chem. 2013 Oct 24;56(20):8019-31. doi: 10.1021/jm4010829. Epub 2013 Oct 14. J Med Chem. 2013. PMID: 24063433

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