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Page 1
Calpain activation in Huntington's disease.
Gafni J, Ellerby LM. Gafni J, et al. J Neurosci. 2002 Jun 15;22(12):4842-9. doi: 10.1523/JNEUROSCI.22-12-04842.2002. J Neurosci. 2002. PMID: 12077181 Free PMC article.
Calpain-1 cleaves and activates caspase-7.
Gafni J, Cong X, Chen SF, Gibson BW, Ellerby LM. Gafni J, et al. J Biol Chem. 2009 Sep 11;284(37):25441-9. doi: 10.1074/jbc.M109.038174. Epub 2009 Jul 18. J Biol Chem. 2009. PMID: 19617626 Free PMC article.
Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM. Tanaka Y, et al. Among authors: gafni j. Neurobiol Dis. 2006 Feb;21(2):381-91. doi: 10.1016/j.nbd.2005.07.014. Epub 2005 Sep 16. Neurobiol Dis. 2006. PMID: 16150600
Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.
Landles C, Sathasivam K, Weiss A, Woodman B, Moffitt H, Finkbeiner S, Sun B, Gafni J, Ellerby LM, Trottier Y, Richards WG, Osmand A, Paganetti P, Bates GP. Landles C, et al. Among authors: gafni j. J Biol Chem. 2010 Mar 19;285(12):8808-23. doi: 10.1074/jbc.M109.075028. Epub 2010 Jan 19. J Biol Chem. 2010. PMID: 20086007 Free PMC article.
80 results