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Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.
Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC. Plum L, et al. Among authors: bruning jc. J Clin Invest. 2006 Jul;116(7):1886-901. doi: 10.1172/JCI27123. Epub 2006 Jun 22. J Clin Invest. 2006. PMID: 16794735 Free PMC article.
Role for neuronal insulin resistance in neurodegenerative diseases.
Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Küstermann E, Arndt S, Jacobs AH, Krone W, Kahn CR, Brüning JC. Schubert M, et al. Among authors: bruning jc. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3100-5. doi: 10.1073/pnas.0308724101. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981233 Free PMC article.
The role of insulin receptor signaling in the brain.
Plum L, Schubert M, Brüning JC. Plum L, et al. Among authors: bruning jc. Trends Endocrinol Metab. 2005 Mar;16(2):59-65. doi: 10.1016/j.tem.2005.01.008. Trends Endocrinol Metab. 2005. PMID: 15734146 Review.
Single copy shRNA configuration for ubiquitous gene knockdown in mice.
Seibler J, Küter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kühn R, Brüning JC, Schwenk F. Seibler J, et al. Among authors: bruning jc. Nucleic Acids Res. 2005 Apr 14;33(7):e67. doi: 10.1093/nar/gni065. Nucleic Acids Res. 2005. PMID: 15831785 Free PMC article.
247 results