Joseph-McCarthy D - Search Results

1

Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.

Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL. Wan ZK, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4941-5. doi: 10.1016/j.bmcl.2006.06.051. Epub 2006 Jun 27. Bioorg Med Chem Lett. 2006. PMID: 16806920

2

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.

Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J. Moretto AF, et al. Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. doi: 10.1016/j.bmc.2005.11.005. Epub 2005 Nov 21. Bioorg Med Chem. 2006. PMID: 16303309

3

Probing acid replacements of thiophene PTP1B inhibitors.

Wan ZK, Follows B, Kirincich S, Wilson D, Binnun E, Xu W, Joseph-McCarthy D, Wu J, Smith M, Zhang YL, Tam M, Erbe D, Tam S, Saiah E, Lee J. Wan ZK, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2913-20. doi: 10.1016/j.bmcl.2007.02.043. Epub 2007 Feb 20. Bioorg Med Chem Lett. 2007. PMID: 17336064

4

Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.

Huang A, Joseph-McCarthy D, Lovering F, Sun L, Wang W, Xu W, Zhu Y, Cui J, Zhang Y, Levin JI. Huang A, et al. Bioorg Med Chem. 2007 Sep 15;15(18):6170-81. doi: 10.1016/j.bmc.2007.06.031. Epub 2007 Jun 20. Bioorg Med Chem. 2007. PMID: 17606376

5

Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.

Wilson DP, Wan ZK, Xu WX, Kirincich SJ, Follows BC, Joseph-McCarthy D, Foreman K, Moretto A, Wu J, Zhu M, Binnun E, Zhang YL, Tam M, Erbe DV, Tobin J, Xu X, Leung L, Shilling A, Tam SY, Mansour TS, Lee J. Wilson DP, et al. J Med Chem. 2007 Sep 20;50(19):4681-98. doi: 10.1021/jm0702478. Epub 2007 Aug 17. J Med Chem. 2007. PMID: 17705360

6

Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.

Wan ZK, Lee J, Hotchandani R, Moretto A, Binnun E, Wilson DP, Kirincich SJ, Follows BC, Ipek M, Xu W, Joseph-McCarthy D, Zhang YL, Tam M, Erbe DV, Tobin JF, Li W, Tam SY, Mansour TS, Wu J. Wan ZK, et al. ChemMedChem. 2008 Oct;3(10):1525-9. doi: 10.1002/cmdc.200800188. ChemMedChem. 2008. PMID: 18798205 No abstract available.

7

Identification of potent and selective TACE inhibitors via the S1 pocket.

Condon JS, Joseph-McCarthy D, Levin JI, Lombart HG, Lovering FE, Sun L, Wang W, Xu W, Zhang Y. Condon JS, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):34-9. doi: 10.1016/j.bmcl.2006.10.004. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17064892

8

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.

Lombart HG, Feyfant E, Joseph-McCarthy D, Huang A, Lovering F, Sun L, Zhu Y, Zeng C, Zhang Y, Levin J. Lombart HG, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4333-7. doi: 10.1016/j.bmcl.2007.05.022. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17531482

9

Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

McKew JC, Lovering F, Clark JD, Bemis J, Xiang Y, Shen M, Zhang W, Alvarez JC, Joseph-McCarthy D. McKew JC, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4501-4. doi: 10.1016/j.bmcl.2003.08.070. Bioorg Med Chem Lett. 2003. PMID: 14643356

10

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.

Gopalsamy A, Yang H, Ellingboe JW, McKew JC, Tam S, Joseph-McCarthy D, Zhang W, Shen M, Clark JD. Gopalsamy A, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2978-81. doi: 10.1016/j.bmcl.2006.02.067. Epub 2006 Mar 20. Bioorg Med Chem Lett. 2006. PMID: 16545564

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