Eckman C - Search Results

1

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Dickey CA, et al. Among authors: eckman c. J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006. J Neurosci. 2006. PMID: 16807328 Free PMC article.

2

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.

Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. Dickey CA, et al. Among authors: eckman c. FASEB J. 2006 Apr;20(6):753-5. doi: 10.1096/fj.05-5343fje. Epub 2006 Feb 7. FASEB J. 2006. PMID: 16464956

3

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L. Dickey CA, et al. Among authors: eckman cb. J Clin Invest. 2007 Mar;117(3):648-58. doi: 10.1172/JCI29715. Epub 2007 Feb 15. J Clin Invest. 2007. PMID: 17304350 Free PMC article.

4

Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD).

Lee WC, Tsoi YK, Dickey CA, Delucia MW, Dickson DW, Eckman CB. Lee WC, et al. Among authors: eckman cb. Neurobiol Dis. 2006 Aug;23(2):273-80. doi: 10.1016/j.nbd.2006.03.005. Epub 2006 Jun 8. Neurobiol Dis. 2006. PMID: 16759875

5

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Dickey CA, et al. Among authors: eckman cb. Mol Neurodegener. 2006 Jul 26;1:6. doi: 10.1186/1750-1326-1-6. Mol Neurodegener. 2006. PMID: 16930453 Free PMC article.

6

Molecular characterization of mutations that cause globoid cell leukodystrophy and pharmacological rescue using small molecule chemical chaperones.

Lee WC, Kang D, Causevic E, Herdt AR, Eckman EA, Eckman CB. Lee WC, et al. Among authors: eckman ea, eckman cb. J Neurosci. 2010 Apr 21;30(16):5489-97. doi: 10.1523/JNEUROSCI.6383-09.2010. J Neurosci. 2010. PMID: 20410102 Free PMC article.

7

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.

Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Dickey CA, et al. Curr Alzheimer Res. 2005 Apr;2(2):231-8. doi: 10.2174/1567205053585927. Curr Alzheimer Res. 2005. PMID: 15974923

8

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. Lewis J, et al. Among authors: eckman c. Science. 2001 Aug 24;293(5534):1487-91. doi: 10.1126/science.1058189. Science. 2001. PMID: 11520987

9

Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy.

Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB. Lee WC, et al. Among authors: eckman cb. FASEB J. 2005 Sep;19(11):1549-51. doi: 10.1096/fj.05-3826fje. Epub 2005 Jun 29. FASEB J. 2005. PMID: 15987783

10

Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy.

Lee WC, Tsoi YK, Troendle FJ, DeLucia MW, Ahmed Z, Dicky CA, Dickson DW, Eckman CB. Lee WC, et al. Among authors: eckman cb. FASEB J. 2007 Aug;21(10):2520-7. doi: 10.1096/fj.06-6169com. Epub 2007 Apr 2. FASEB J. 2007. PMID: 17403939

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