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Page 1
Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation.
Vaidehi N, Schlyer S, Trabanino RJ, Floriano WB, Abrol R, Sharma S, Kochanny M, Koovakat S, Dunning L, Liang M, Fox JM, de Mendonça FL, Pease JE, Goddard WA 3rd, Horuk R. Vaidehi N, et al. Among authors: dunning l. J Biol Chem. 2006 Sep 15;281(37):27613-20. doi: 10.1074/jbc.M601389200. Epub 2006 Jul 12. J Biol Chem. 2006. PMID: 16837468 Free article.
A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection.
Horuk R, Clayberger C, Krensky AM, Wang Z, Grone HJ, Weber C, Weber KS, Nelson PJ, May K, Rosser M, Dunning L, Liang M, Buckman B, Ghannam A, Ng HP, Islam I, Bauman JG, Wei GP, Monahan S, Xu W, Snider RM, Morrissey MM, Hesselgesser J, Perez HD. Horuk R, et al. Among authors: dunning l. J Biol Chem. 2001 Feb 9;276(6):4199-204. doi: 10.1074/jbc.M007457200. Epub 2000 Oct 27. J Biol Chem. 2001. PMID: 11054419 Free article.
Species selectivity of a small molecule antagonist for the CCR1 chemokine receptor.
Liang M, Rosser M, Ng HP, May K, Bauman JG, Islam I, Ghannam A, Kretschmer PJ, Pu H, Dunning L, Snider RM, Morrissey MM, Hesselgesser J, Perez HD, Horuk R. Liang M, et al. Among authors: dunning l. Eur J Pharmacol. 2000 Feb 11;389(1):41-9. doi: 10.1016/s0014-2999(99)00863-8. Eur J Pharmacol. 2000. PMID: 10686294
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
Liang M, Mallari C, Rosser M, Ng HP, May K, Monahan S, Bauman JG, Islam I, Ghannam A, Buckman B, Shaw K, Wei GP, Xu W, Zhao Z, Ho E, Shen J, Oanh H, Subramanyam B, Vergona R, Taub D, Dunning L, Harvey S, Snider RM, Hesselgesser J, Morrissey MM, Perez HD. Liang M, et al. Among authors: dunning l. J Biol Chem. 2000 Jun 23;275(25):19000-8. doi: 10.1074/jbc.M001222200. J Biol Chem. 2000. PMID: 10748002 Free article.
CCR1-specific non-peptide antagonist: efficacy in a rabbit allograft rejection model.
Horuk R, Shurey S, Ng HP, May K, Bauman JG, Islam I, Ghannam A, Buckman B, Wei GP, Xu W, Liang M, Rosser M, Dunning L, Hesselgesser J, Snider RM, Morrissey MM, Perez HD, Green C. Horuk R, et al. Among authors: dunning l. Immunol Lett. 2001 Apr 2;76(3):193-201. doi: 10.1016/s0165-2478(01)00172-9. Immunol Lett. 2001. PMID: 11306147
Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process.
Islam I, Yuan S, Wei RG, Xu W, Morrissey M, Mohan R, Zheng D, DiMella A, Dunning L, Snider M, Subramanyam B, Tseng JL, Bryant JA, Buckman BO. Islam I, et al. Among authors: dunning l. Bioorg Med Chem Lett. 2018 May 15;28(9):1459-1463. doi: 10.1016/j.bmcl.2018.03.090. Epub 2018 Mar 31. Bioorg Med Chem Lett. 2018. PMID: 29628327
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